Author

M. Shan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. A. Lyssiotis· 4 shared L. Zhang· 3 shared B. Magnuson· 2 shared H. Hong· 2 shared L. Franchi· 2 shared N. Mbah· 2 shared P. Sajjakulnukit· 2 shared A. Andren· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

C. A. Lyssiotis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

N. Mbah, A. Myers, C. Chung, J. Thompson, H. Hong, P. Sajjakulnukit, Z. Nwosu, M. Shan, S. Sweha, D. Maydan, B. Chen, L. Zhang, B. Magnuson, Z. Zui, D. Wahl, , C. A. Lyssiotis

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

bioRxiv · Mar 1, 2022 · PreprintCancer Biology

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

H. Hong, N. Mbah, M. Shan, K. Loesel, L. Lin, P. Sajjakulnukit, A. Andren, A. Hayashi, B. Magnuson, Z. Li, Y. Xie, L. Zhang, Y. L. Lei, A. Opipari, R. J. Arguello, , C. A. Lyssiotis

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

bioRxiv · Oct 1, 2021 · PreprintImmunology

Human norovirus infection of primary B cells triggers immune activation in vitro

C. Mirabelli, M. K. Jones, V. Young, A. Kolawole, I. Owusu, M. Shan, B. H. Abuaita, I. Grigorova, S. K. Lundy, C. A. Lyssiotis, V. K. Ward, S. M. Karst, C. E. Wobus

This study shows human norovirus infects primary B cells, induces functional changes, and the NS1 protein affects B cell proliferation and metabolism in vitro.

bioRxiv · May 14, 2021 · PreprintMicrobiology

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

F. Puca, F. Yu, C. Bertolacci, P. Pettazzoni, A. Carugo, E. Huang-Hobbs, J. Liu, C. Zanca, F. Carbone, E. Del Poggetto, J. Gumin, P. Dasgupta, S. Seth, F. F. Lang, E. Sulman, , G. Draetta

This study identifies MCAD as a critical enzyme for fatty acid metabolism in GBM, showing its essential role in preventing mitochondrial damage and apoptosis.

bioRxiv · Sep 28, 2020 · PreprintCancer Biology

Optical excitation and detection of neuronal activity

C. Hu, R. Sam, M. Shan, V. Nastasa, M. Wang, T. Kim, M. Gillette, P. Sengupta, G. Popescu

This paper demonstrates phase imaging as a label-free method to detect optogenetic-induced intracellular transport in neurons.

bioRxiv · Jul 26, 2018Bioengineering