V. Yeliseyev

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile.

This study shows that TcdE holin is essential for toxin secretion and virulence in C. difficile, as tcdE mutants exhibit reduced toxin release and less virulence in mice.

Clostridium scindens colonization of gnotobiotic mice promotes a chronic unresolving infection with Clostridioides difficile

This study shows that C. scindens colonization in gnotobiotic mice reduces acute C. difficile infection severity but does not prevent chronic infection development.

Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model

This study shows that a proanthocyanidin-enriched cranberry extract alters bacterial community dynamics in a gnotobiotic mouse model, with transient increases in mucin-degrading and anti-inflammatory bacteria.

Bacteriophages dynamically modulate the gut microbiota and metabolome

This study shows that bacteriophages affect gut bacteria and metabolites in mice, with cascading effects on the microbiome and implications for phage therapy.