M. A. Kebede

Optimised proteomic analysis of insulin granules from MIN6 β-cells identifies Scamp3, a novel regulator of insulin secretion and content

This study identifies 211 proteins associated with insulin secretory granules in MIN6 β-cells, including SCAMP3, which regulates insulin storage and secretion.

VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity

This study shows that VPS41 deletion causes insulin degradation and loss of beta-cell identity in mice, with lysosomal inhibition rescuing insulin content.

Phytochemical Screening, Investigation of the toxic and hepatoprotective effect of leaves of Prunus africana-using mice model

This study screens phytochemicals and evaluates the toxic and hepatoprotective effects of Prunus africana leaves in mice, finding it safe and effective against CCl4-induced liver damage.

Insulin sensitivity is preserved in mice made obese by feeding a high starch diet

This study shows that mice fed a high starch diet become obese but remain insulin sensitive, unlike those on a high fat diet, with differences in ceramide levels and lipogenesis contributing to this effect.

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion

This study shows that VPS41 deletion in pancreatic beta-cells causes diabetes by impairing insulin secretory granule formation and secretion.

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.