Author

C. M. Bisbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:metabolism & bioenergetics· 5 Organism:mouse· 4 Assay:metabolomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. B. Hurley· 6 shared D. T. Hass· 5 shared B. M. Robbings· 4 shared I. R. Sweet· 3 shared M. Sadilek· 3 shared A. M. Rountree· 2 shared W. M. Cleghorn· 2 shared A. P. Valencia· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersBiochemistry

J. B. Hurley

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6 papers

Recent·Most cited

In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

D. T. Hass, E. Giering, J. Y. S. Han, C. M. Bisbach, K. Pandey, B. M. Robbings, T. O. Mundinger, N. D. Nolan, S. H. Tsang, N. J. Philp, N. S. Peachey, J. B. Hurley

The paper demonstrates that photoreceptors supply lactate to the RPE, supporting a metabolic exchange between these retinal cells.

bioRxiv · Apr 10, 2023 · PreprintBiochemistry

Monocarboxylate Transporter 1 (MCT1) mediates succinate export in the retina

C. M. Bisbach, D. T. Hass, J. B. Hurley

The paper identifies MCT1 as the transporter mediating succinate export from retinas but finds no MCT-mediated import into RPE.

bioRxiv · Nov 19, 2021Biochemistry

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

K. A. Tsantilas, W. M. Cleghorn, C. M. Bisbach, J. A. Whitson, D. T. Hass, B. M. Robbings, M. Sadilek, J. D. Linton, A. M. Rountree, A. P. Valencia, M. T. Sweetwyne, M. D. Campbell, H. Zhang, C. S. R. Jankowski, I. R. Sweet, , J. B. Hurley

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

bioRxiv · Apr 6, 2021Biochemistry

Succinate metabolism uncouples retinal pigment epithelium mitochondria

D. T. Hass, C. M. Bisbach, B. M. Robbings, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

bioRxiv · Feb 10, 2021 · PreprintBiochemistry

Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium.

C. M. Bisbach, D. T. Hass, B. M. Robbings, A. M. Rountree, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.

bioRxiv · Jan 17, 2020Biochemistry

Mitochondrial Ca2+ influences photoresponse recovery, metabolism, and mitochondrial localization in cone photoreceptors

R. A. Hutto, C. M. Bisbach, F. Abbas, D. C. Brock, W. M. Cleghorn, E. D. Parker, B. H. Bauer, W. Ge, F. Vinberg, J. B. Hurley, S. E. Brockerhoff

This study shows that low mitochondrial Ca2+ uptake in zebrafish cone photoreceptors affects photoresponse recovery, metabolism, and mitochondrial localization, with increased MCU expression altering these processes.

bioRxiv · Jan 3, 2019Cell Biology