C. O'Callaghan

Single cell-guided prenatal derivation of primary epithelial organoids from the human amniotic and tracheal fluids.

The paper derives epithelial organoids from human amniotic and tracheal fluids to model congenital malformations and predict disease outcomes.

PI4KIII3β inhibition reduces rhinovirus associated cell shedding and ciliary dysfunction

This study shows that inhibiting PI4KIIIβ reduces rhinovirus replication and ciliated cell loss in respiratory epithelial cultures from healthy and COPD patients.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Cell-intrinsic differences between human airway epithelial cells from children and adults

The paper compares airway epithelial cells from children and adults, finding intrinsic differences in transcriptional profiles and regenerative capacity.

High-content screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

The paper develops a high-content screening method using differentiated respiratory epithelium from PCD patients to evaluate readthrough therapies for rare respiratory diseases.