Author

Y.-H. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Microbiology· 2 Ecology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

L. Wang· 3 shared C. H. Rivas· 2 shared D. G. Edwards· 2 shared D. Hoffman· 2 shared E. Chen· 2 shared F. Liu· 2 shared H. L. Chan· 2 shared H. Wang· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

L. Wang

Author profile →

6 papers

Recent·Most cited

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

F. Liu, Y. Ding, Z. Xu, X. Hao, T. Pan, G. Miles, C. H. Rivas, D. Hoffman, D. G. Edwards, E. Chen, H. Wang, H. L. Chan, J. Liu, L. Wu, L. Yu, , X. Zhang

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

bioRxiv · May 7, 2024Cancer Biology

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Z. Xu, F. Liu, Y. Ding, T. Pan, Y.-H. Wu, J. Liu, I. L. Bado, W. Zhang, L. Wu, Y. Gao, X. Hao, L. Yu, D. G. Edwards, H. L. Chan, S. Aguirre, , X. H.- F. Zhang

bioRxiv · May 7, 2024 · PreprintCancer Biology

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

R.-H. Wang, P.-R. Chen, Y.-T. Chen, Y.-C. Chen, Y.-H. Chu, C.-C. Chien, P.-C. Chien, S.-Y. Lo, Z.-L. Wang, M.-C. Tsou, S.-Y. Chen, G.-S. Chiu, W.-L. Chen, Y.-H. Wu, L. Wang, , K.-T. Lin

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

bioRxiv · Sep 2, 2023Cancer Biology

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

Y.-f. Pan, H. Zhao, Q.-y. Gou, P.-b. Shi, J.-h. Tian, Y. Feng, K. Li, W.-h. Yang, D. Wu, G. Tang, B. Zhang, Z. Ren, S. Peng, G.-y. Luo, S.-j. Le, , M. Shi

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

bioRxiv · Aug 28, 2023 · PreprintEcology

Chemical-induced degradation of PreS2 mutant surface antigen reverses HBV- mediated hepatocarcinogenesis

J. Y. Yang, Y.-H. Wu, M. Y.-C. Pan, Y.-T. Chiou, R. K.-L. Lee, T.-N. Li, L. Wang

This study identifies ABT199 as an inhibitor of PreS2-LHBS that reverses HBV-mediated hepatocarcinogenesis through microautophagy-induced degradation.

bioRxiv · Jan 24, 2022 · PreprintMicrobiology

Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

Y.-H. Wu, Y. Yang, C.-H. Chen, C.-J. Hsiao, T.-N. Li, K.-J. Liao, B.-S. Chen, L. Wang

This paper shows that HBV uses aerobic glycolysis to support its biosynthesis by interacting with PKM2, and that restoring PKM2 activity can reduce viral production and oncogenesis.

bioRxiv · Aug 10, 2020Microbiology