Carola Hunte

Modular assembly of mitochondrial complex III from a dynamic matrix domain pool

This study reveals how mitochondrial complex III assembles from preformed matrix domain modules, showing dynamic subunit exchange and the role of specific residues in assembly and disease.

Human NHE1 binds full-length calcineurin with high affinity and inhibits substrate dephosphorylation

This study quantifies the interaction between full-length human calcineurin and NHE1-CnBD under different activation states and shows NHE1 inhibits substrate dephosphorylation.

Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

Molecular determinants of selective and high-affinity binding of the scaffold protein PDZK1 to the transporter URAT1

This study identifies molecular determinants of high-affinity PDZK1 binding to URAT1 using biophysical and structural methods, revealing species-specific interactions.

SLC25A48 is a human mitochondrial choline transporter

This study identifies SLC25A48 as a human mitochondrial choline transporter and shows that loss-of-function mutations lead to elevated choline levels in urine and plasma.