Author

D. B. Keskin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. J. Wu· 2 shared K. R. Clauser· 2 shared N. Hacohen· 2 shared S. A. Carr· 2 shared S. Klaeger· 2 shared S. Sarkizova· 2 shared A. Apffel· 1 shared A. Nachshon· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

C. J. Wu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

N. L. Truex, S. Mohapatra, M. Melo, J. Rodriguez, N. Li, W. Abraham, D. Sementa, F. Touti, D. B. Keskin, C. J. Wu, D. J. Irvine, R. Gomez-Bombarelli, B. L. Pentelute

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

bioRxiv · Aug 22, 2023 · PreprintImmunology

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

S. Weingarten-Gabbay, S. Klaeger, S. Sarkizova, L. R. Pearlman, D.-Y. Chen, M. R. Bauer, H. B. Taylor, H. L. Conway, C. H. Tomkins-Tinch, Y. Finkel, A. Nachshon, M. Gentili, K. D. Rivera, D. B. Keskin, C. M. Rice, , P. C. Sabeti

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

bioRxiv · Oct 2, 2020 · PreprintImmunology

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

T. Ouspenskaia, T. Law, K. R. Clauser, S. Klaeger, S. Sarkizova, F. Aguet, B. Li, E. Christian, B. A. Knisbacher, P. M. Le, C. R. Hartigan, H. Keshishian, A. Apffel, G. Oliveira, W. Zhang, , A. Regev

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

bioRxiv · Feb 12, 2020 · PreprintCancer Biology