Author

R. L. Leibel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Egli· 3 shared C. A. LeDuc· 2 shared D. J. Williams· 2 shared L. Sui· 2 shared B. J. Gonzalez· 1 shared C. A. Doege· 1 shared C. N. Goulbourne· 1 shared C. U. Nielsson· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

D. Egli

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity

Y. Zhang, L. Sui, Q. Du, L. Haataja, Y. Yin, R. Viola, S. Xu, C. U. Nielsson, R. L. Leibel, F. Barbetti, P. Arvan, D. Egli

This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.

bioRxiv · Sep 1, 2023Cell Biology

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

B. J. Gonzalez, H. Zhao, J. Niu, D. J. Williams, J. Lee, C. N. Goulbourne, Y. Xing, Y. Wang, J. Oberholzer, X. Chen, C. A. LeDuc, W. K. Chung, H. M. Colecraft, J. Gromada, Y. Shen, , D. Egli

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

bioRxiv · Jan 26, 2021Cell Biology

Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

L. Wang, Y. Liu, G. Stratigopoulos, S. Panigrahi, L. Sui, C. A. Leduc, H. J. Glover, M. C. De Rosa, L. C. Burnett, D. J. Williams, L. Shang, R. Goland, S. H. Tsang, S. Wardlaw, D. Egli, , R. L. Leibel

This study investigates how BBS mutations affect neuron function and signaling in iPSC-derived neurons, identifying impaired ciliary function and signaling pathways related to energy homeostasis.

bioRxiv · Oct 29, 2020Cell Biology

Methodologic Issues in Doubly Labeled Water Measurements of Energy Expenditure During Very Low-Carbohydrate Diets

K. D. Hall, J. Guo, K. Y. Chen, R. L. Leibel, M. L. Reitman, M. Rosenbaum, S. R. Smith, E. Ravussin

This study compares energy expenditure measurements using doubly labeled water (DLW) and respiratory chambers during very low-carbohydrate diets, finding that DLW overestimates energy expenditure when not adjusted for respiratory quotient changes.

bioRxiv · Oct 23, 2018Physiology