Author

J. L. Kirkland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

T. Tchkonia· 4 shared D. Jurk· 2 shared N. LeBrasseur· 2 shared A. Lagnado· 1 shared A. Parini· 1 shared A. Walaszczyk· 1 shared A. Xue· 1 shared B. J. Cottle· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

T. Tchkonia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

S. Chaib, J. A. Lopez-Dominguez, M. Lalinde, N. Prats, I. Marin, K. Meyer, M. I. Munoz, M. Aguilera, L. Mateo, C. S.-O. Attolini, S. Llanos, M. Escorihuela, S. Perez-Ramos, F. Al-Shahrour, T. P. Cash, , M. Serrano

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

bioRxiv · Nov 4, 2022 · PreprintCancer Biology

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

D. Saul, R. L. Kosinsky, E. J. Atkinson, M. L. Doolittle, X. Zhang, N. LeBrasseur, R. Pignolo, P. Robbins, L. Niedernhofer, Y. Ikeno, D. Jurk, J. Passos, L. Hickson, A. Xue, D. Monroe, , M.D, S. Khosla

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

bioRxiv · Dec 10, 2021Cell Biology

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

Q. Xu, Q. Fu, Z. Li, H. Liu, Y. Wang, X. Lin, R. He, X. Zhang, J. Campisi, J. L. Kirkland, Y. Sun

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

bioRxiv · Apr 14, 2021 · PreprintCell Biology

Aged-senescent cells contribute to impaired heart regeneration

F. C. Lewis-McDougall, P. J. Ruchaya, E. Domenjo-Vila, T. S. Teoh, L. Prata, B. J. Cottle, J. E. Clark, P. P. Punjabi, W. Awad, D. Torella, T. Tchkonia, J. L. Kirkland, G. M. Ellison-Hughes

This study shows that aged-senescent cardiac progenitor cells impair heart regeneration and that eliminating them improves cardiac function in aged mice.

bioRxiv · Oct 1, 2018Physiology

Length-independent telomere damage drives cardiomyocyte senescence

R. Anderson, A. Lagnado, D. Maggiorani, A. Walaszczyk, E. Dookun, J. Chapman, J. Birch, H. Salmonowicz, M. Ogrodnik, D. Jurk, C. Proctor, C. Correia-Melo, S. Victorelli, E. Fielder, R. Berlinguer-Palmini, , J. F. Passos

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.

bioRxiv · Aug 17, 2018Cell Biology