K. Gao

Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1

Myostatin gene deletion alters gut microbiota stimulating fast-twitch glycolytic muscle growth

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies

This study identifies high-frequency SARS-CoV-2 mutations that may compromise multiple monoclonal antibody therapies in clinical trials using a topology-based deep learning approach.

Functionalized extracellular matrix scaffolds loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

Response of methanogen community to elevation of cathode potentials in the presence of magnetite

This study shows that magnetite enables methanogens to adapt to higher cathode potentials in electrochemical reactors, enhancing electromethanogenesis.

Dissecting the landscape of activated CMV-stimulated CD4+ T cells in human by linking single-cell RNA-seq with T-cell receptor sequencing

This study uses single-cell RNA-seq and TCR sequencing to analyze CMV-reactivated CD4+ T cell subsets, revealing their heterogeneity, functional roles, and interactions.

A fluorescent L-2-hydroxyglutarate biosensor

The paper develops a fluorescent biosensor for L-2-hydroxyglutarate (L-2-HG) using LhgR, a transcription factor that recognizes L-2-HG, and demonstrates its application in monitoring L-2-HG levels in bacterial and human cells.

Germline-encoded TCR-MHC contacts promote TCR V gene bias in umbilical cord blood T cell repertoire

The paper uses QTL mapping to show MHC variants bias TRBV gene usage in UCB samples, revealing germline-encoded TCR-MHC contacts influence TCR repertoire.

A potential role for epigenetic processes in the acclimation response to elevated pCO2 in the model diatom Phaeodactylum tricornutum

This study examines transcriptomic changes in the diatom Phaeodactylum tricornutum under elevated pCO2, finding down-regulation of chromatin structure genes and up-regulation of histone acetylation enzymes and transposable elements.