Author

Darius Moaddeli

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Assay:metabolomics· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Aeowynn J. CoakleyiD· 4 shared Ryo Higuchi‐SanabriaiD· 4 shared Gilberto GarciaiD· 3 shared Peter J. MulleniD· 3 shared Athena AlcalaiD· 2 shared Bérénice Anath BenayouniD· 2 shared Edgar EsparzaiD· 2 shared George WangiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

Aeowynn J. CoakleyORCID

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Author profile →

4 papers

Recent·Most cited

Form and function of actin impacts actin health and aging.

Maxim Averbukh, Hunter T. Nelson, Tiffany V. Wang, Caitlin M. Lange, Athena Alcala, Juri Kim, Daniella Suh, Matthew Vega, Shihong Max Gao, Naibedya Dutta, Khristina E. Young, Rebecca Aviles Barahona, Aeowynn J. Coakley, Joe A. Gerke, Sofia F. Odron, , Ryo Higuchi‐Sanabria

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

iScience · Aug 24, 2026Peer-reviewedCell Biology

The aging mouse lipidome

Edgar Esparza, Steven E. Pilley, Xuanyi Shi, Preeti R Iyengar, Shruti Sivaraman, George Wang, Racheal Mulondo, Sriraksha Bharadwaj Kashyap, Darius Moaddeli, Aeowynn J. Coakley, Ryo Higuchi‐Sanabria, Whitaker Cohn, Peter J. Mullen

This study maps age- and sex-related lipid changes across 10 mouse organs, revealing organ-specific and sex-dependent patterns in the lipidome during aging.

bioRxiv · Feb 4, 2026 · PreprintMolecular Biology

A metabolic atlas of mouse aging

Steven E. Pilley, Dominik Awad, Djakim Latumalea, Connie New, Edgar Esparza, Shuo Yuan Wang, Xuanyi Shi, Li Zhang, Maximilian Unfried, Jasinda H. Lee, Ernst Schmid, Ipsita Mohanty, Jenna L. E. Blum, Shivaanishaa Raventhiran, Esther S.P. Wong, , Peter J. Mullen

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

Cell Metabolism · Nov 25, 2025Peer-reviewedMolecular Biology

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

Aeowynn J. Coakley, Adam J. Hruby, Jing Wang, Andrew Bong, Tripti Nair, Carmen M. Ramos, Athena Alcala, Daniel Hicks, Maxim Averbukh, Naibedya Dutta, Darius Moaddeli, Camilla Pearson, Cynthia J. Siebrand, Mattias de los Rios Rogers, Arushi Sahay, , Ryo Higuchi‐Sanabria

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Communications Biology · Nov 24, 2025Peer-reviewedCell Biology