Author

B. Guigas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 6 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Zawistowska-Deniziak· 5 shared B. Everts· 4 shared F. Otto· 4 shared J. M. Lambooij· 4 shared A. Ozir-Fazalalikhan· 3 shared L. R. Pelgrom· 3 shared M. Yazdanbakhsh· 3 shared T. A. Patente· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

A. Zawistowska-Deniziak

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Author profile →

7 papers

Recent·Most cited

AMPK activation induces RALDHhigh tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

E. C. Brombacher, T. A. Patente, A. J. van der Ham, T. J. A. Moll, F. Otto, F. W. M. Verheijen, E. A. Zaal, A. H. de Ru, R. T. N. Tjokrodirijo, C. R. Berkers, P. A. van Veelen, B. Guigas, B. Everts

This study shows that AMPK activation makes human dendritic cells more tolerogenic by altering their metabolism, specifically increasing RALDH activity and changing lipid and glucose metabolism.

bioRxiv · Jul 4, 2023 · PreprintImmunology

Metabolic sensor AMPK licenses CD103+ dendritic cells to induce Treg responses

T. Patente, E. Brombacher, G. Heieis, L. Pelgrom, A. Zawistowska-Deniziak, F. Otto, A. Ozir-Fazalalikhan, A. van der Ham, B. Guigas, J. A. M. Barbuto, B. Everts

This study shows AMPK is essential for retinoic acid-induced CD103+ dendritic cells to promote Treg responses and control Type 2 immunity.

bioRxiv · Feb 21, 2023 · PreprintImmunology

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

C. Liu, M. Schönke, B. Spoorenberg, J. Lambooij, H. van der Zande, E. Zhou, M. E. Tushuizen, A.-C. Andreasson, A. Park, S. Oldham, M. Uhrbom, I. Ahlstedt, Y. Ikeda, K. Wallenius, X.-R. Peng, , P. C. Rensen

This study shows that FGF21 overexpression in the liver reduces lipotoxicity, inflammation, and fibrosis in NASH by blocking lipid influx and macrophage activation.

bioRxiv · Sep 20, 2022Pathology

Fasciola hepatica Fatty Acid Binding Protein 1 modulates T cell polarization by promoting dendritic cell thrombospondin-1 secretion without affecting metabolic homeostasis in obese mice

A. Zawistowska-Deniziak, J. M. Lambooij, T. A. Patente, M. Lapinski, H. J. van der Zande, K. Basalaj, C. de Korne, M. A. Chaye, T. Gasan, L. J. Norbury, M. Giera, A. Zaldumbide, H. H. Smits, B. Guigas

bioRxiv · Apr 1, 2022Immunology

LKB1 signalling in dendritic cells controls whole-body metabolic homeostasis by limiting T helper 17 priming

H. J. P. van der Zande, E. C. Brombacher, J. M. Lambooij, L. R. Pelgrom, A. Zawistowska-Deniziak, T. A. Patente, G. A. Heieis, F. Otto, A. Ozir-Fazalalikhan, M. Yazdanbakhsh, B. Everts, B. Guigas

This study shows that LKB1 in dendritic cells limits T helper 17 cell priming, thereby protecting against obesity-induced metabolic dysfunctions.

bioRxiv · Oct 14, 2021 · PreprintImmunology

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation

M. Embgenbroich, H. J. van der Zande, L. Hussaarts, J. Schulte-Schrepping, L. R. Pelgrom, N. Garcia-Tardon, L. Schlautmann, I. Stoetzel, K. Handler, J. M. Lambooij, A. Zawistowska-Deniziak, L. Hoving, K. de Ruiter, M. Wijngaarden, H. Pijl, , S. Burgdorf

This study shows that soluble mannose receptor (sMR) promotes pro-inflammatory macrophage activation and metaflammation by inhibiting CD45 phosphatase activity, leading to metabolic dysfunctions in obesity.

bioRxiv · Sep 29, 2020 · PreprintImmunology

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type-2 immunity-independent inhibition of food intake

H. J. P. van der Zande, M. A. Gonzalez, K. de Ruiter, R. Wilbers, N. Garcia-Tardon, M. van Huizen, K. van Noort, L. R. Pelgrom, J. M. Lambooij, A. Zawistowska-Deniziak, F. Otto, A. Ozir-Fazalalikhan, D. van Willigen, M. Welling, J. Poles, , B. Guigas

This paper shows that the helminth glycoprotein omega-1 improves metabolic health in obese mice by reducing food intake, independent of type 2 immunity.

bioRxiv · Jul 3, 2020Immunology