Author

E. G. Rakasz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:non-human primate· 2 Organism:rat· 2 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. B. Ward· 3 shared A. K. Rendahl· 2 shared C. A. Cottrell· 2 shared D. R. Burton· 2 shared D. Sok· 2 shared E. Connick· 2 shared G. Ozorowski· 2 shared G. Song· 2 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

A. B. Ward

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

F. Zhao, Z. T. Berndsen, N. Pedreno-Lopez, A. Burns, J. D. Allen, S. Barman, W.-H. Lee, S. Chakraborty, S. Gnanakaran, L. M. Sewall, G. Ozorowski, O. Limbo, G. Song, P. Yong, S. Callaghan, , D. Sok

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

bioRxiv · Dec 22, 2021Immunology

CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection

M. S. Pampusch, H. M. Abdelaal, E. K. Cartwright, J. S. Molden, B. C. Davey, J. D. Sauve, A. K. Rendahl, E. G. Rakasz, E. Connick, E. A. Berger, P. J. Skinner

This study evaluates CAR/CXCR5-T cell therapy in SIV-infected rhesus macaques, showing reduced viral loads and safety, with potential for HIV remission.

bioRxiv · Jul 26, 2021Immunology

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

H. L. Turner, R. Andrabi, C. A. Cottrell, S. T. Richey, G. Song, S. Callaghan, F. Anzanello, T. J. Moyer, W. Abraham, M. Melo, M. Silva, N. Scaringi, E. G. Rakasz, Q. J. Sattentau, D. J. Irvine, , A. B. Ward

This study shows that off-target antibodies from HIV trimer vaccines cause trimer disassembly, exposing more off-target epitopes and driving further off-target immune responses.

bioRxiv · Feb 16, 2021Immunology

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

C. A. Cottrell, J. van Schooten, C. A. Bowman, M. Yuan, D. Oyen, M. Shin, R. Morpurgo, P. van der Woude, M. van Breemen, J. L. Torres, R. Patel, J. Gross, L. M. Sewall, J. Copps, G. Ozorowski, , M. J. van Gils

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

bioRxiv · Feb 5, 2020Immunology

Absence of SIV-specific CD8+ T cells in germinal centers may set the stage for persistent infection

S. Li, J. M. Folkvord, K. J. Kovacs, R. K. Wagstaff, G. Mwakalundwa, A. K. Rendahl, E. G. Rakasz, E. Connick, P. J. Skinner

The paper shows that SIV-specific CD8+ T cells are excluded from germinal centers early in infection, potentially contributing to persistent viral infection.

bioRxiv · Sep 3, 2018Immunology

Highly Efficient Maternal-Fetal Zika Virus Transmission in Pregnant Rhesus Macaques

S. M. Nguyen, K. M. Antony, D. M. Dudley, S. Kohn, H. Simmons, B. Wolfe, M. S. Salamat, L. B. Teixeira, G. J. Wiepz, T. H. Thoong, M. T. Aliota, A. M. Weiler, G. L. Barry, K. L. Weisgrau, L. J. Vosler, , T. G. Golos

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

bioRxiv · May 11, 2017Pathology