E. R. Chapman

Label-free observation of individual solution phase molecules

This paper introduces a label-free technique to detect individual solution-phase molecules using microcavities, achieving high signal-to-noise ratios and resolving molecular radius and isomer mixtures.

Synaptotagmin-9 and Tomosyn-1 molecular complex regulates Stx1A SNAREs to inhibit insulin secretion from pancreatic beta-cells

This study shows that synaptotagmin-9 inhibits insulin secretion by forming a complex with Tomosyn-1 and Stx1A, reducing SNARE complex formation in pancreatic beta-cells.

Digital nanoreactors for control over absolute stoichiometry and spatiotemporal behavior of receptors within lipid bilayers

The paper introduces digital nanoreactors to control and study the stoichiometry, spatial arrangement, and temporal dynamics of membrane protein interactions.

Optimizing multifunctional fluorescent ligands for intracellular labeling

The paper designs cell-permeable multifunctional ligands for HaloTag fusions that enable protein labeling and translocation, using Si-rhodamines with low KL-Z and high logD7.4 values.

Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis

The paper shows that actin filaments and membrane compression from synaptic vesicle exocytosis drive ultrafast endocytosis at synapses.

VAMP2 AND SYNAPTOTAGMINS ARE RELATIVELY IMMOBILE ON CHROMAFFIN GRANULE MEMBRANES: IMPLICATIONS FOR MEMBRANE FUSION AND FUSION PORE EXPANSION

The paper measures the mobility of VAMP2 and synaptotagmins on chromaffin granule membranes and finds they are relatively immobile, suggesting this affects fusion pore kinetics.