Author

A. N. Tkachuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:imputation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. B. Grimm· 4 shared L. D. Lavis· 4 shared T. A. Brown· 4 shared H. Choi· 2 shared J. Lippincott-Schwartz· 2 shared L. Xie· 2 shared R. Patel· 2 shared A. C. Kokotos· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCell Biology

J. B. Grimm

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Author profile →

5 papers

Recent·Most cited

A series of spontaneously blinking dyes for super-resolution microscopy

K. L. Holland, S. E. Plutkis, T. A. Daugird, A. Sau, J. B. Grimm, B. P. English, Q. Zheng, S. Dave, F. Rahman, L. Xie, P. Dong, A. N. Tkachuk, T. A. Brown, R. H. Singer, Z. J. Liu, , L. D. Lavis

This paper introduces a series of spontaneously blinking dyes with adjustable duty cycles for improved single-molecule localization microscopy in cells and dense structures.

bioRxiv · Feb 23, 2024Cell Biology

iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

J. S. Marvin, A. C. Kokotos, M. Kumar, C. Pulido, A. N. Tkachuk, J. S. Yao, T. A. Brown, T. A. Ryan

The paper develops iATPSnFR2, a high dynamic range fluorescent ATP sensor for real-time subcellular ATP monitoring, showing improved performance over previous versions.

bioRxiv · Aug 24, 2023Biochemistry

Optimizing multifunctional fluorescent ligands for intracellular labeling

P. Kumar, J. D. Vevea, A. N. Tkachuk, K. Campbell, E. T. Watson, A. X. Ayala, J. B. Grimm, E. R. Chapman, D. J. Solecki, L. D. Lavis

The paper designs cell-permeable multifunctional ligands for HaloTag fusions that enable protein labeling and translocation, using Si-rhodamines with low KL-Z and high logD7.4 values.

bioRxiv · Jul 2, 2022 · PreprintCell Biology

Deuteration improves small-molecule fluorophores

J. B. Grimm, L. Xie, J. C. Casler, R. Patel, A. N. Tkachuk, H. Choi, J. Lippincott-Schwartz, T. A. Brown, B. S. Glick, Z. Liu, L. D. Lavis

This study shows that deuteration of small-molecule fluorophores enhances their brightness, chromostability, and photostability in cellular imaging.

bioRxiv · Aug 17, 2020 · PreprintCell Biology

Optimization and functionalization of red-shifted rhodamine dyes

J. B. Grimm, A. N. Tkachuk, H. Choi, B. Mohar, N. Falco, R. Patel, J. Lippincott-Schwartz, T. A. Brown, L. D. Lavis

This study optimizes red-shifted rhodamine dyes to improve their performance and enables functionalization with different chemical groups.

bioRxiv · Dec 20, 2019 · PreprintCell Biology