M. L. Suva

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution

The paper introduces PATH, a framework to quantify heritability and plasticity of cellular phenotypes in somatic evolution using single-cell data from mouse and human samples.

Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas

The paper identifies four immunomodulatory programs in glioma-associated myeloid cells using scRNA-seq and shows they are driven by microenvironmental cues and therapies, not cell type or mutation status.

Integrative spatial analysis reveals a multi-layered organization of glioblastoma

This study uses spatial transcriptomics and proteomics to reveal three modes of cellular organization in glioblastoma, with hypoxia driving a 5-layered global architecture.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors

This study integrates single-cell RNA-seq data from 1,163 tumors across 24 types to identify 41 consensus transcriptional programs and 11 hallmarks of intra-tumor heterogeneity.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.