Author

G. M. Genin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Biophysics· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Assay:imaging· 4 Organism:mouse· 4 Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

F. Xu· 3 shared F. Alisafaei· 2 shared G. Huang· 2 shared H. Y. Suleiman· 2 shared I. Kurtaliaj· 2 shared J. H. Miner· 2 shared S. Thomopoulos· 2 shared T. J. Lu· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiophysics

F. Xu

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Author profile →

11 papers

Recent·Most cited

Stability of navigation in catheter-based endovascular procedures

C. M. Hartquist, J. V. Lee, M. Y. Qiu, C. Suskin, V. Chandrasekaran, H. R. Lowe, M. A. Zayed, J. W. Osbun, G. M. Genin

The paper identifies catheter herniation as a bifurcation phenomenon and presents a mathematical stability criterion to predict and prevent it using mechanical and imaging data.

bioRxiv · Jun 2, 2023 · PreprintBioengineering

Deep Learning Reveals How Cells Pull, Buckle, and Navigate Tissue-Like Environments

A. Padhi, A. Daw, M. Sawhney, M. M. Talukder, A. Agashe, G. M. Genin, F. Alisafaei, S. Kale, A. Karpatne, A. Nain

This paper introduces DLFM, a deep learning method to measure real-time cell forces in tissue-like environments, revealing new mechanical behaviors during migration and differentiation.

bioRxiv · Oct 24, 2022 · PreprintBiophysics

A Self-Healing, Viscoelastic Hydrogel Promotes Healing of Brain Lesions

Y. Hu, Y. Jia, S. Wang, Y. Ma, G. Huang, T. Ding, D. Feng, G. M. Genin, Z. Wei, F. Xu

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

bioRxiv · May 5, 2022 · PreprintBioengineering

Multimodal Thrombectomy Device for Treatment of Acute Deep Venous Thrombosis

U. N. Ismail, R. A. Rowe, J. L. Cashin, G. M. Genin, M. Zayed

This paper describes a novel thrombectomy device for treating acute deep venous thrombosis, showing reduced distal embolization and improved vein clearance in ex vivo tests.

bioRxiv · Feb 21, 2022Bioengineering

Effects of tendon viscoelasticity in the distribution of forces over sutures in a model tendon-to-bone repair

Y. Huang, e. hoppe, I. Kurtaliaj, V. Birman, S. Thomopoulos, G. M. Genin

This study examines how tendon viscoelasticity affects force distribution across sutures in tendon-to-bone repairs and shows that optimized suture stiffness and spacing can balance forces effectively.

bioRxiv · Nov 9, 2021 · PreprintBioengineering

An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures.

J. Shumeng, F. Alisafaei, H. Yuan, X. Peng, Y.-Y. Huang, J. H. Miner, G. M. Genin, H. Y. Suleiman

The paper develops an ex vivo culture model of kidney podocytes to study injury recovery, revealing mechanosensitive sarcomere-like structures that template synaptopodin.

bioRxiv · Nov 3, 2021Cell Biology

Toughening mechanisms for the attachment of architectured materials: The mechanics of the tendon enthesis

M. Golman, A. C. Abraham, I. Kurtaliaj, B. P. Marshall, Y. J. Hu, A. G. Schwartz, X. E. Guo, V. Birman, P. J. Thurner, G. M. Genin, S. Thomopoulos

The paper identifies toughening mechanisms in the tendon enthesis using a mouse model, revealing architectural adaptations that optimize strength and toughness across scales.

bioRxiv · May 17, 2021Bioengineering

3D Visualization of the Podocyte Actin Network using Integrated Membrane Extraction, Electron Microscopy, and Deep Learning

C. Qu, R. Roth, C. Loitman, D. Hammad, G. M. Genin, J. H. Miner, H. Y. Suleiman

This paper develops a new visualization technique to study 3D actin networks in podocytes, revealing structural changes in healthy and injured states.

bioRxiv · Jan 29, 2021 · PreprintCell Biology

Transient K+ current explains cross-species differences in the effects of myofibroblasts on myocytes

F. Liu, H. Wu, X. Yang, Y. Dong, G. Huang, G. M. Genin, T. J. Lu, F. Xu

The paper develops a mathematical model to explain cross-species differences in myofibroblast effects on cardiomyocytes, identifying transient K+ currents as a key factor.

bioRxiv · Nov 2, 2020 · PreprintBiophysics

Negative durotaxis: cell movement toward softer environments

A. Isomursu, K.-Y. Park, J. Hou, C. Bo, G. Shamsan, B. Fuller, J. Kasim, M. M. Mahmoodi, T. J. Lu, G. M. Genin, F. Xu, M. Lin, M. Distefano, J. Ivaska, D. J. Odde

The paper identifies negative durotaxis, where cells migrate toward softer environments, and shows that integrin adhesion and motor-clutch dynamics drive this behavior in glioblastoma and neurites.

bioRxiv · Oct 27, 2020 · PreprintBiophysics

Fluorescence correlation spectroscopy and photon count histograms in small domains. Part I: General theory

E. L. Elson, Y. Jiang, B. Xu, A. Melnykov, G. M. Genin

This paper derives general forms of fluorescence correlation spectroscopy (FCS) and photon counting histogram (PCH) for bounded systems, enabling accurate quantification of molecular kinetics in finite domains.

bioRxiv · Nov 20, 2019 · PreprintBiophysics