G. Guo

Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY

The paper identifies SOFTI, a specific inhibitor of SPY O-fucosyltransferase, through virtual screening and validates its effects on O-fucosylation in Arabidopsis and tomato.

Identification and Characterization of a Novel Major Facilitator Superfamily (MFS) Efflux Pump SA09310 Mediating Tetracycline Resistance in Staphylococcus aureus

This study identifies and characterizes SA09310 as a novel tetracycline resistance efflux pump in Staphylococcus aureus, showing it mediates drug resistance through H+-dependent extrusion.

Investigating the Consistency of Extracellular Vesicle Production from Breast Cancer Subtypes Using CELLine Adherent Bioreactors

This study shows that CELLine AD 1000 bioreactors can consistently produce EVs from multiple breast cancer subtypes, with stable core protein content over time.

Isolation, identification and molecular characterization of Aeromonas spp. from farmed loach (Misgurnus anguillicaudatus)

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

Vaccination-induced rapid protection against bacterial pneumonia via training alveolar macrophage in mice

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

The Arabidopsis R-SNARE VAMP714 is essential for polarization of PIN proteins in the establishment and maintenance of auxin gradients.

This study shows that the Arabidopsis R-SNARE VAMP714 is essential for PIN protein polarization, auxin transport, and root development.

Gut dysbiosis protects against liver injury in autophagy deficient mice by FXR-FGF15 feedback signaling

This study shows that gut dysbiosis reduces liver injury in autophagy-deficient mice through FXR-FGF15 signaling, suggesting caution in antibiotic use during liver disease.

Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening

This study identifies four clinically used drugs with high binding capacity to SARS-CoV main protease, a potential target for treating 2019-nCoV infection.

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

Helicobacter pylori-induced adrenomedullin modulates IFN-γ-producing T-cell responses and contribute to gastritis

This study shows that H. pylori-induced adrenomedullin promotes inflammation in gastritis by enhancing IFN-γ-producing T-cell responses through AKT and STAT3 phosphorylation and IL-12 production.

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during trophectoderm and inner cell mass specification

This study identifies CDX2-regulated genes and regulatory elements in mouse embryos, revealing how CDX2 represses pluripotent genes during trophectoderm and inner cell mass specification.