H. Peterziel

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies

This study develops a glioblastoma cell line from a genetic mouse model that mimics human glioblastoma features, enabling preclinical testing of immunotherapies.

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

This study uses human brain organoids and single-cell transcriptomics to model GBM invasion, identifying transcriptional changes and potential therapeutic targets.