J. Brown

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

The paper improves a prostate cancer mouse model with a bioluminescent reporter to monitor tumor progression and shows that double knockout of Pten and Trp53 leads to castrate-resistant, locally invasive tumors.

The paper uses accelerometry to measure energy expenditure in homing pigeons and finds that dominant birds have higher movement but no linear correlation between rank and energy expenditure.

This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.

This study shows that aberrant IL7RA signaling in human hematopoietic progenitors leads to B-cell differentiation arrest and Ph-like BCP-ALL development in mice.

This study investigates whether a cost of resistance is necessary for adaptive therapy to delay cancer progression, finding that cell turnover modulates this requirement depending on tumor growth conditions.

The paper investigates the role of HY5 in light-mediated stomatal development in Arabidopsis and finds that HY5 does not significantly regulate stomatal development despite potential promoter interactions.

This paper introduces Cryo-OrbiSIMS for 3D molecular imaging of bacterial biofilms, revealing the spatial distribution of quorum sensing molecules and membrane components in Pseudomonas aeruginosa.

The paper identifies and traps a mesoderm-biased pluripotent state in human stem cells using WNT signaling and lysophosphatidic acid.

The paper dissects phylogenetic signal in a plant dataset to resolve conflicts and identify unresolved relationships, finding support for certain placements but uncertainty in others.

This study uses atomic force microscopy to compare the biophysical properties of bacterial capsules in Streptococcus mitis and S. pneumoniae with identical serotypes, revealing differences in mechanical behavior linked to virulence.

This paper introduces three novel concepts to aid in designing multi-drug adaptive therapies for cancer by analyzing tumor evolution dynamics and treatment strategies.

This study identifies hypervirulent Clostridium perfringens strains and microbiome changes associated with necrotic enteritis in broiler chickens.

This paper analyzes a bio-orthogonally modified herpes simplex virus (HSV) to reveal novel aspects of virus entry and processing.

This study compares vibrotactile and joint-torque feedback in a myoelectric prosthesis, finding that both improve object discrimination accuracy, though no significant difference exists between the two modalities.

The paper develops a mathematical model to optimize neoadjuvant combination therapy for ER+ breast cancer by balancing tumor burden and metastatic potential using game theory.

This paper develops a logic-based method to represent and resolve conflicts in phylogenomic node concepts across competing avian evolutionary reconstructions.

This study shows that fungicides can increase fungal infections in amphibians by reducing their resistance, despite direct toxicity to the pathogen.

The paper analyzes concordance and conflict in avian phylogenies over time, finding persistent conflicts in major clades despite advances in phylogenetic methods.