J. He

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

This study conducts a meta-analysis of 12 articles to evaluate the protective effect of FMDV VP1 protein on animals, finding a significant protective effect with a combined effect value of -0.66.

The paper identifies GSK3 inhibitors as synthetic lethal with cohesin mutations, revealing Wnt pathway activation as a therapeutic target in cohesin mutant cancers.

This study shows that DYNC1LI2 restores endolysosomal dynamics and cellular homeostasis in cystinosis by rescuing LAMP2A localization and reducing ER stress and mitochondrial fragmentation.

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This study investigates the molecular mechanisms of 2019-nCoV binding to human ACE2 and its evolutionary advantages over SARS-CoV using computational methods.

This study evaluates the binding of ritonavir, lopinavir, and darunavir to SARS-CoV-2 proteases using molecular modeling, finding that ritonavir and lopinavir inhibit CEP_C30 more effectively than darunavir inhibits PLVP.

This paper introduces a method to correct missing-wedge artifacts in filamentous tomograms using template-based constrained deconvolution, improving automated segmentation of structures like actin-filament bundles.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.

This study characterizes the mutational and transcriptomic landscapes of a rare prostate basal cell carcinoma using single-cell sequencing, revealing unique gene expression and regulatory patterns.

The paper tests how changes in geomagnetic field intensity affect migration-related traits in the brown planthopper, finding responses in morphology, behavior, and physiology.

This paper develops a platform to independently control cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing for optoelectronic tuning.

This study uses single-cell RNA sequencing to identify naive B cells associated with better prognosis in human HCC by analyzing a mouse model and mapping to the TCGA database.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

FungalRoot compiles and provides a comprehensive database of plant mycorrhizal associations, offering data on colonization intensity and metadata to support ecological and evolutionary research.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This study shows miR-590-5p reduces radio-resistance in pancreatic cancer by inhibiting autophagy through targeting ATG3.

This study characterizes MthfD, a 5-CH3-THF dehydrogenase essential for dicamba degradation in R. dicambivorans Ndbn-20, showing its enzymatic activity and role in THF regeneration.

This study identifies and characterizes a novel pic gene cluster in Alcaligenes faecalis JQ135 responsible for complete picolinic acid degradation into the tricarboxylic acid cycle.

The paper detects Leishmania spp. in snakes from Northwest China and identifies three species using phylogenetic analysis.

This study identifies and characterizes a novel decarboxylase, PicC, involved in the catabolism of picolinic acid in Alcaligenes faecalis JQ135, demonstrating its role in converting 3,6-dihydroxypicolinic acid to 2.5-dihydroxypyridine.

This study investigates the effect of L. reuteri on immune parameters and gut microbiota, revealing sex-specific differences in immune response and microbial composition.

The paper assesses IVIM MRI parameter reproducibility after removing motion-contaminated and poorly fitted data, finding good repeatability and reproducibility for Dslow and PF.

This paper identifies HpaM, a novel FAD-dependent monooxygenase in Alcaligenes faecalis JQ135, which catalyzes 2-decarboxylative hydroxylation of 5HPA to produce 2,5-DPH.