Author

J. I. Johnsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. Kogner· 4 shared N. Baryawno· 3 shared S. Fransson· 3 shared T. K. Olsen· 3 shared T. Martinsson· 3 shared C. Bartenhagen· 2 shared C. Tummler· 2 shared J. Milosevic· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

P. Kogner

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Author profile →

5 papers

Recent·Most cited

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

R. Vaid, K. Thombare, A. Mendez, R. Burgos-Panadero, A. Djos, D. Jachimowicz, K. Ihrmark Lundberg, C. Bartenhagen, N. Kumar, C. Tummler, C. Sihlbom, S. Fransson, J. I. Johnsen, P. Kogner, T. Martinsson, , T. Mondal

This study shows METTL3 modifies TERRA lncRNA with m6A, promoting R-loop formation that targets TERRA to telomeres, and inhibiting METTL3 disrupts this process in ALT+ neuroblastoma cells.

Nucleic Acids Research · Mar 21, 2024Peer-reviewedCancer Biology

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.

N. F. H. N. van Bree, A.-S. Oppelt, S. Lindstrom, L. Zhou, L. Boutin, J. I. Johnsen, L. Brautigam, M. T. Wilhelm

This paper develops a zebrafish model for medulloblastoma drug testing, showing that neural stem cell culture conditions enhance tumor cell homing and aggressiveness, enabling high-throughput screening.

bioRxiv · Feb 21, 2024Cancer Biology

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

T. K. Olsen, C. Dyberg, B. Embaie, A. Alchahin, J. Milosevic, J. Otte, C. Tummler, I. H. Myrberg, E. M. Westerhout, J. Koster, R. Versteeg, P. Kogner, J. I. Johnsen, D. B. Sykes, N. Baryawno

This study identifies DHODH as a prognostic marker and therapeutic target in neuroblastoma, showing its inhibition improves survival in preclinical models and suggests combination therapy with temozolomide.

bioRxiv · Sep 25, 2021Cancer Biology

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

J. Milosevic, S. Fransson, M. Gulyas, G. Gallo-Oller, T. K. Olsen, D. Treis, M. Wickstrom, L. H. Elfman, B. Sveinbjornsson, F. Hertwig, C. Bartenhagen, S. Reinsbach, M. Wilhelm, F. Abel, N. Javanmardi, , P. Kogner

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

T. K. Olsen, J. Otte, S. Mei, P. Kameneva, A. Bjoerklund, E. Kryukov, Z. Hou, A. Johansson, E. Sundstroem, T. Martinsson, S. Fransson, J. I. Johnsen, P. Kogner, I. Adameyko, P. V. Kharchenko, N. Baryawno

The paper identifies a subpopulation of malignant Schwann cell precursor-like cells in neuroblastoma that connects adrenergic and mesenchymal tumor cells, suggesting intratumoral plasticity mechanisms.

bioRxiv · May 4, 2020 · PreprintCancer Biology