J. Kang

This study shows ATP induces protein folding, inhibits aggregation, and stabilizes proteins by mediating water-protein-ion interactions, with triphosphate being key but aggregation-prone, while ATP prevents this.

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

This paper demonstrates the use of near-infrared cyanine voltage-sensitive dye imaging to functionally localize the cavernous nerve network in real time during rat prostate surgery.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

The paper benchmarks predictive models for kinase inhibitor potencies using crowdsourced data and identifies new compound-kinase interactions.

This study shows that Padi2-mediated citrullination is essential for wound response and tissue regeneration in zebrafish by promoting histone modification and cell proliferation in the notochord bead.

This study identifies that combining RNA Polymerase I inhibitor CX-5461 with TOP1 inhibitor topotecan enhances DNA damage response and efficacy in high-grade serous ovarian cancer.

This study shows that a high-phytate/low-calcium diet causes crystal nephropathies, renal phosphate wasting, and bone loss in rats through tubular dysfunction and altered mineral absorption.

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.

The paper shows ATP induces protein folding, inhibits aggregation, and increases stability by combining adenosine and triphosphate.

This study determines the cryo-EM structure of the COMPASS complex bound to H2Bub and nucleosome, revealing how H2Bub activates H3K4 methylation by modulating the Set1 ARM.

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

This study shows that neonatal-derived IL-17-producing γδ T cells prevent spontaneous atopic dermatitis by maintaining skin homeostasis and preventing dysbiosis and inflammation.

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.

This study identifies SmbHLH37 as an antagonist of SmMYC2 in regulating jasmonate-mediated phenolic acid biosynthesis in Salvia miltiorrhiza.

This study identifies the TMEM106B cytoplasmic domain as intrinsically disordered, enabling its dynamic and transient interactions with multiple proteins.

The paper demonstrates the feasibility of delivering a voltage-sensitive dye to brain tissue using Regadenoson to enhance BBB permeability, as shown by increased fluorescence signal residence time.