Author

A. D. Gruber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

J. Trimpert· 6 shared A. Abdelgawad· 4 shared E. Wyler· 4 shared J. M. Adler· 4 shared M. Landthaler· 4 shared M. Witzenrath· 4 shared C. Drosten· 3 shared C. Goffinet· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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6 shared papersImmunology

J. Trimpert

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

S. Peidli, G. Nouailles, E. Wyler, J. M. Adler, S. Kunder, A. Voss, J. Kazmierski, F. Pott, P. Pennitz, D. Postmus, L. G. Teixeira Alves, C. Goffinet, A. D. Gruber, N. Bluethgen, M. Witzenrath, , S. D. Praktiknjo

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

bioRxiv · Aug 25, 2023Immunology

Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamsters

L. G. Teixeira Alves, M. Baumgardt, J. Hoppe, T. C. Firsching, J. M. Adler, G. Mastrobuoni, J. Grobe, K. Hoenzke, S. Kempa, A. D. Gruber, A. C. Hocke, J. Trimpert, E. Wyler, M. Landthaler

This study shows that Ganetespib, an HSP90 inhibitor, reduces SARS-CoV-2 replication and inflammation in vitro and improves clinical outcomes in infected Syrian golden hamsters.

bioRxiv · Dec 27, 2022 · PreprintMicrobiology

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

G. Nouailles, J. M. Adler, P. Pennitz, S. Peidli, G. Teixeira Alves, M. Baumgart, J. Bushe, A. Voss, A. Langenhagen, F. Pott, J. Kazmierski, C. Goekeri, S. Simmons, N. Xing, C. Langner, , J. Trimpert

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

bioRxiv · May 16, 2022Immunology

Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

M. Aznaourova, N. Schmerer, H. Janga, Z. Zhang, K. Pauck, J. Hoppe, S. M. Volkers, D. Wendisch, P. Georg, M. Guendisch, E. Mack, C. Skevaki, C. Keller, C. Bauer, W. Bertrams, , L. N. Schulte

The paper identifies PIRAT, a lncRNA regulating monocyte immunity in COVID-19 via PU.1 feedback, and shows its role in alarmin production.

bioRxiv · Nov 5, 2021 · PreprintImmunology

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

S. Rothenberger, D. L. Hurdiss, M. Walser, F. Malvezzi, J. Mayor, S. Ryter, H. Moreno, N. Liechti, A. Bosshart, C. Iss, V. Calabro, A. Cornelius, T. Hospodarsch, A. Neculcea, T. Looser, , Vassell

This paper describes ensovibep, a trispecific DARPin that inhibits SARS-CoV-2 variants by targeting the spike protein, showing potent antiviral activity and protection in animal models.

bioRxiv · Feb 3, 2021 · PreprintImmunology

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

G. Nouailles, E. Wyler, P. Pennitz, D. Postmus, D. Vladimirova, J. Kazmierski, F. Pott, K. Dietert, M. Mülleder, V. Farztdinov, B. Obermayer, S.-M. Wienhold, S. Andreotti, T. Höfler, B. Sawitzki, , M. Witzenrath

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

bioRxiv · Dec 18, 2020Immunology

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

J. Kreye, S. M. Reincke, H.-C. Kornau, E. Sanchez-Sendin, V. M. Corman, H. Liu, M. Yuan, N. C. Wu, X. Zhu, C.-C. D. Lee, J. Trimpert, M. Hoeltje, K. Dietert, L. Stoeffler, N. von Wardenburg, , N. Osterrieder

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

bioRxiv · Aug 15, 2020Immunology

Age-dependent progression of SARS-CoV-2 infection in Syrian hamsters

N. Osterrieder, L. D. Bertzbach, K. Dietert, A. Abdelgawad, D. Vladimirova, D. Kunec, D. Hoffmann, M. Beer, A. D. Gruber, J. Trimpert

This study compares SARS-CoV-2 infection progression in young and aged Syrian hamsters, finding age-related differences in weight loss, immune response, and lung recovery.

Viruses · Jul 20, 2020Peer-reviewedMicrobiology