M. Landthaler

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamsters

This study shows that Ganetespib, an HSP90 inhibitor, reduces SARS-CoV-2 replication and inflammation in vitro and improves clinical outcomes in infected Syrian golden hamsters.

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

A single dose of a recombinant murine CMV vaccine expressing SARS-CoV-2 spike protein provides long-lasting immunity against multiple variants in mice.

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

Global analysis of human-to-mouse contact-dependent intercellular mRNA and lncRNA transfer in cell culture

The paper quantifies mRNA and lncRNA transfer between human and mouse cells in co-culture, showing non-selective transfer and correlation with donor gene expression.

ENGINEERING, DECODING AND SYSTEMS-LEVEL CHARACTERIZATION OF CHIMPANZEE CYTOMEGALOVIRUS

This paper engineers, decodes, and characterizes chimpanzee cytomegalovirus (CCMV) to explore its potential as a model for human CMV, identifying novel genes, regulatory elements, and functional roles.

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts

The paper uses single-cell RNA-seq to analyze antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts, identifying interferon-stimulated genes and immune-related pathways.

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

Loss of macp{Psi} ribosomal RNA modification is a major feature of cancer

The paper identifies a cancer-specific rRNA modification loss in multiple cancers, linking it to oncogenic translational signatures and potential therapeutic targets.

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

Integrative functional genomics decodes herpes simplex virus 1

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.