Author

J. L. Yee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. H. Spitzer· 3 shared I. Tenvooren· 2 shared K. J. Hiam-Galvez· 2 shared N. W. Cho· 2 shared R. DeBarge· 2 shared T. L. H. Okholm· 2 shared A. A. Ardeshir· 1 shared A. Cheung· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

M. H. Spitzer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

M. K. Rahim, T. L. H. Okholm, K. B. Jones, E. E. McCarthy, C. C. Liu, J. L. Yee, S. J. Tamaki, D. M. Marquez, I. Tenvooren, K. Wai, A. Cheung, B. R. Davidson, V. Johri, B. Samad, W. E. O'Gorman, , M. H. Spitzer

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

bioRxiv · Nov 8, 2022 · PreprintImmunology

T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFa Inflammation.

N. W. Cho, S. M. Guldberg, B. Y. Nabet, J. Z. Yu, E. J. Kim, K. J. Hiam-Galvez, J. L. Yee, R. DeBarge, I. Tenvooren, N. A. Ashitey, F. Lynce, D. A. Dillon, J. M. Rosenbluth, M. H. Spitzer

The paper identifies a novel mechanism of ICI resistance where T cells drive inflammatory resistance via IL-1 and TNF in tumors, with implications for therapy.

bioRxiv · Sep 20, 2022Immunology

Transient dendritic cell activation diversifies the T cell response to acute infection

K. J. Hiam-Galvez, R. Debarge, C. A. Lareau, N. W. Cho, J. L. Yee, T. L. H. Okholm, M. H. Spitzer

The paper shows that transient dendritic cell activation during acute infection shapes T cell fate by timing their priming and influencing whether they become effector or memory cells.

bioRxiv · Sep 26, 2021 · PreprintImmunology

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation

K. K. A. Van Rompay, K. J. Olstad, R. L. Sammak, J. Dutra, J. K. Watanabe, J. L. Usachenko, R. Immareddy, J. W. Roh, A. Verma, Y. Shaan Lakshmanappa, B. Schmidt, C. Di Germanio, N. Rizvi, M. Stone, G. Simmons, , J. R. Reader

This study treats SARS-CoV-2 infected macaques with high-titer convalescent plasma, showing reduced lung inflammation without affecting virus replication.

bioRxiv · Sep 1, 2021 · PreprintImmunology