C. A. Lareau

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

Transient dendritic cell activation diversifies the T cell response to acute infection

The paper shows that transient dendritic cell activation during acute infection shapes T cell fate by timing their priming and influencing whether they become effector or memory cells.

A direct RNA-protein interaction atlas of the SARS-CoV-2 RNA in infected human cells

This study maps direct RNA-protein interactions of SARS-CoV-2 RNA in infected human cells using RAP-MS, identifying host factors, regulators, and potential drug targets involved in viral replication and host defense.