Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics
A. Vahabikashi, S. Sivagurunathan, F. A. S. Nicdao, Y. L. Han, C. Y. Park, X. Wong, J. R. Tran, G. G. Gundersen, K. Reddy, G. G. Luxton, M. Guo, J. J. Fredberg, Y. Zheng, S. A. Adam, R. D. Goldman
This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.
bioRxiv · May 12, 2021Biophysics