Author

S. Sivagurunathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1 Physiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:cryo-EM· 3 Approach:experimental assay· 3 Approach:microscopy & imaging analysis· 3 Organism:mouse· 3 Research Focus:protein structure prediction· 3 Organism:human· 2

Frequent Co-Authors

O. Medalia· 4 shared R. D. Goldman· 4 shared M. Eibauer· 3 shared M. S. Weber· 3 shared J. J. Fredberg· 2 shared S. A. Adam· 2 shared Y. Turgay· 2 shared A. A. Nathan· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCell Biology

O. Medalia

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Bridging Imaging Users to Imaging Analysis - A community survey

S. Sivagurunathan, S. Marcotti, C. J. Nelson, M. L. Jones, D. J. Barry, T. J. A. Slater, K. W. Eliceiri, B. A. Cimini

The paper surveys imaging users and developers to identify needs and gaps in image analysis tools and education, highlighting demands for documentation, tutorials, and user-friendly software.

bioRxiv · Jun 5, 2023Scientific Communication & Education

Vimentin filaments integrate low complexity domains in a highly complex helical structure

M. Eibauer, M. S. Weber, R. Kronenberg-Tenga, C. T. Beales, R. Boujemaa-Paterski, Y. Turgay, S. Sivagurunathan, J. Kraxner, S. Koester, R. D. Goldman, O. Medalia

This study determines the 3D structure of vimentin intermediate filaments, revealing how disordered domains contribute to their mechanical properties.

bioRxiv · May 22, 2023Biochemistry

Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex

H. Wu, Y. Shen, S. Sivagurunathan, M. S. Weber, S. A. Adam, J. H. Shin, J. J. Fredberg, O. Medalia, R. Goldman, D. A. Weitz

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

Proceedings of the National Academy of Sciences · Mar 2, 2022Peer-reviewedCell Biology

Oral glucose feeding enhances adherence of quiescent lymphocytes to fibronectin via non-canonical insulin signalling.

A. C. T. Mallu, S. Sivagurunathan, D. Paul, H. Aggarwal, A. A. Nathan, M. M. Ravi, R. Boppana, K. Jagavelu, M. K. Santra, M. Dixit

The paper shows oral glucose increases lymphocyte adhesion to fibronectin via non-canonical insulin signaling involving IGF-1R and PLCγ1.

bioRxiv · Oct 13, 2021 · PreprintPhysiology

The molecular architecture of vimentin filaments

M. Eibauer, M. S. Weber, Y. Turgay, S. Sivagurunathan, R. D. Goldman, O. Medalia

This study reveals the subnanometer structure of vimentin filaments in mouse cells, showing their helical symmetry and molecular composition.

bioRxiv · Jul 15, 2021 · PreprintCell Biology

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

A. Vahabikashi, S. Sivagurunathan, F. A. S. Nicdao, Y. L. Han, C. Y. Park, X. Wong, J. R. Tran, G. G. Gundersen, K. Reddy, G. G. Luxton, M. Guo, J. J. Fredberg, Y. Zheng, S. A. Adam, R. D. Goldman

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

bioRxiv · May 12, 2021Biophysics

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

M. Weber, M. Eibauer, S. Sivagurunathan, T. Magin, R. D. Goldman, O. Medalia

This study uses cryo-electron microscopy to reveal the structural heterogeneity of keratin 5/keratin 14 filaments, showing variations in diameter and subunit organization.

bioRxiv · May 12, 2021Cell Biology