J. Wang

This study shows that claudin-4 reconstituted in vesicles forms tight interfaces that partition membrane proteins, supporting its role as a molecular fence in epithelial polarization.

The paper develops a gene therapy system that uses telomerase activity to kill cancer cells in mice without affecting normal cells.

This study shows that an immune-responsive retrotransposon in Arabidopsis influences disease resistance gene expression through its LTR.

This study presents the cryo-EM structure of the mouse TRPC4 ion channel, revealing unique features that contribute to its ion selectivity and evolutionary diversity within the TRP family.

This paper introduces a method to infer tumor phylogeny and deconvolute structural variations from bulk genomic data, showing it works well on simulated and breast cancer data.

This study identifies novel germline V and J alleles in Rhesus macaques by analyzing BCR repertoires and validates them using whole genome sequencing and alignment reference.

This paper introduces ctPCR, a CRISPR-based method for detecting and typing DNA, validated for HPV subtypes and cervical carcinoma cells.

This study uses GWAS and RNA-Seq to identify genetic differences between lesion and nodal resistance in pea to Sclerotinia sclerotiorum, finding distinct genetic mechanisms for each resistance type.

The paper identifies a major genetic locus, PtFT2, that controls local adaptation and adaptive life history variation in European aspen across a latitudinal gradient.

This study uses microscopy to show RNase E and ribosomes are spatially organized in Caulobacter crescentus, with clustering linked to RNA availability and rRNA gene location.

The paper shows that the functional distinction between β- and γ-actin is determined by their gene sequence, not their protein sequence, through genome editing in mice.

The paper determines cryo-EM structures of the nucleolar large subunit processome in different states, revealing how assembly factors prevent premature folding and enable distinct folding pathways.

This study uses 18F-FDG PET/CT imaging and molecular assays to assess BAT aging in LmnaG609G/G609G mice, finding reduced metabolic activity and increased apoptosis/senescence compared to wild-type mice.

The paper investigates a classic bistable genetic switch in E. coli, revealing new cell fate potentials and switching kinetics beyond the classical two-state model.

This study identifies an RNA-mediated dimerization mechanism that regulates APOBEC3H DNA deaminase activity, localization, and antiviral function.

This study shows type 2 diabetes increases centrosome amplification in PBMCs through AKT-ROS-dependent activation of ROCK1 and 14-3-3σ.

This study identifies a genetic variant affecting telomere length in C. elegans and finds no correlation between telomere length and fitness traits.