J. Wang

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This paper combines VAMS and mPlex-Flu assays to measure influenza antibody responses, showing high consistency between finger-stick and venous blood samples.

The paper compares ploidy in cardiac interstitial cells between rodents and large mammals, finding species-specific differences in tetraploidy and its functional implications.

The paper shows that copy-number variation of pheromone receptor genes in C. elegans is shaped by selection and gene flow, contributing to differences in pheromone responses across habitats.

This paper develops a microfluidic and machine learning platform for rapid bacteria identification and antimicrobial susceptibility testing using digital PCR and melt analysis.

The paper investigates how eIF5B facilitates the transition from translation initiation to elongation in yeast using single-molecule fluorescence microscopy.

This study investigates RACK1's exchange dynamics on and off the ribosome using fluorescent labeling and biochemical analyses, showing its stable binding and limited conformational changes.

This study shows that Dickeya dadantii uses cell-length heterogeneity to balance virulence and growth during infection, with short cells being virulent and filamentous cells supporting rapid growth.

This study identifies genes regulating cell death in Staphylococcus aureus through a genome-wide screen, revealing both death-resistant and death-sensitive mutants with implications for virulence and antibiotic persistence.

This study identifies PRH1 as a target of ARF7 and LBDs in auxin signaling, showing its role in lateral root development through interaction with GATA23.

This paper demonstrates a gene therapy approach using NF-κB-activated CRISPR/Cas9 to specifically target and kill cancer cells without affecting normal cells.

This study develops a CRISPR-assistant trans enhancer to efficiently activate gene expression by combining dCas9-VP64/sgRNA with a CMV enhancer.

The paper improves in vitro culture conditions for Schistosoma mansoni, enabling sustained egg production and revealing male-induced female maturation and a novel nuclear receptor involved in sexual development.

This study designs a universal primer set for CAOB amoA genes and reveals their ubiquity and high abundance across diverse ecosystems.

This study shows that colonizing tsetse flies with Enterobacter inhibits trypanosome infection and reduces susceptibility to entomopathogenic bacteria without significant fitness costs.

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

This study shows that H3K9me3 prevents nucleosome deposition at euchromatic promoters, affecting gene expression in C. elegans.

The paper investigates 5-hydroxymethylcytosine (5hmC) as a potential biomarker for pancreatic cancer, showing distinct distributions in tumor and adjacent tissues.

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

This study examines the sterilization effects of cavitation-shock interactions on marine Vibrio sp. through experimental and modeling approaches.

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

The paper investigates the ecological niches of Pristionchus and Panagrellus nematodes, finding they feed on decomposing vegetal matter and are transported by various arthropods, challenging the notion that they are exclusively necromenic.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

The paper analyzes miRNA expression in serum exosomes from healthy controls, latent TB, and active TB to identify differentially expressed miRNAs and their potential roles in TB progression.

This paper conducts a GWAS on the Hybrid Mouse Diversity Panel to identify genetic loci associated with noise-induced cochlear synaptopathy and identifies 4 novel loci and candidate genes.