Author

J. Watanabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Immunology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:statistical model· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Usachenko· 3 shared K. K. A. Van Rompay· 3 shared A. Singapuri· 2 shared J. B. Stuart· 2 shared L. L. Coffey· 2 shared R. Immareddy· 2 shared A. Ardeshir· 1 shared A. G. Pletnev· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

J. Usachenko

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Distribution theories for genetic line of least resistance and evolvability measures

J. Watanabe

This paper develops distribution theories for genetic line of least resistance and evolvability measures to provide statistical frameworks for interpreting genetic constraints in multivariate evolution.

bioRxiv · Oct 7, 2023Evolutionary Biology

Exact expressions and numerical evaluation of average evolvability measures for characterizing and comparing G matrices

J. Watanabe

The paper derives exact expressions for average evolvability measures of G matrices and provides numerical evaluation methods to replace previous approximations.

bioRxiv · Nov 2, 2022Evolutionary Biology

CiDRE+ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

Y. Mitsui, T. Suzuki, K. Kuniyoshi, J. Inamo, K. Yamaguchi, M. Komuro, J. Watanabe, M. Edamoto, S. Li, T. Kouno, S. Oba, T. Hosoya, S. Koyama, N. Sakaguchi, D. M. Standley, , T. Satoh

This study identifies IL-10-driven M2c macrophages as key contributors to severe COVID-19 by facilitating SARS-CoV-2 infection and highlights CiDRE as a potential therapeutic target.

bioRxiv · Sep 30, 2022 · PreprintImmunology

Distinct upper airway epithelium interferon-stimulated and profibrotic gene expression between adult and infant rhesus macaques infected with SARS-CoV-2

S. N. Langel, C. Garrido, C. Phan, T. Travieso, T. DeMarco, Z.-M. Ma, J. R. Reader, K. J. Olstad, R. L. Sammak, Y. Shaan Lakshmanappa, J. W. Roh, J. Watanabe, J. Usachenko, R. Immareddy, R. E. Pollard, , M. Blasi

This study compares SARS-CoV-2 infection effects in adult and infant rhesus macaques, finding distinct interferon-stimulated and profibrotic gene expression patterns in upper airway epithelium.

bioRxiv · Feb 12, 2022Immunology

Statistics of eigenvalue dispersion indices: quantifying the magnitude of phenotypic integration

J. Watanabe

This paper derives analytical expressions for eigenvalue dispersion indices under multivariate normality and validates their sampling properties for phenotypic integration analysis.

bioRxiv · Jun 19, 2021Evolutionary Biology

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectors

D. Lemos, J. B. Stuart, W. Louie, A. Singapuri, A. L. Ramirez, J. Watanabe, J. Usachenko, R. Keesler, C. Sanchez-San Martin, T. Li, C. Martyn, G. Oliveira, S. Saraf, N. D. Grubaugh, K. Andersen, , L. L. Coffey

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

bioRxiv · Aug 11, 2020Microbiology

Wing musculature reconstruction in extinct flightless auks (Pinguinus and Mancalla) reveals incomplete convergence with penguins (Spheniscidae) due to differing ancestral states

J. Watanabe, D. J. Field, H. Matsuoka

bioRxiv · Jul 22, 2020Evolutionary Biology

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

K. K. A. Van Rompay, L. L. Coffey, T. Kapoor, A. Gazumyan, R. I. Keesler, A. Jurado, A. Peace, M. Agudelo, J. Watanabe, J. Usachenko, A. Singapuri, R. Immareddy, A. Ardeshir, J. B. Stuart, S. Bournazos, , D. F. Robbiani

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

bioRxiv · Jan 31, 2020Immunology

Pirfenidone attenuates lung fibrotic fibroblast-mediated fibrotic responses to transforming growth factor-β1

J. Jin, S. Togo, K. Kadoya, m. tulafu, Y. Namba, M. Moe Iwai, J. Watanabe, K. Nagahama, T. Okabe, M. Hidayat, Y. Kodama, H. Kitamura, T. Ogura, N. Kitamura, K. Ikeo, , K. Takahashi

This study shows pirfenidone reduces fibrotic responses in lung fibroblasts by inhibiting CTHRC1, suggesting it as a potential therapeutic target for lung fibrosis.

bioRxiv · Aug 27, 2018Cell Biology