Author

S. Y. Jung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 5 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. L. Walker· 2 shared D. N. Tripathi· 2 shared F. Li· 2 shared K. J. Verhey· 2 shared M. Karki· 2 shared R. Dere· 2 shared R. K. Jangid· 2 shared R. N. H. Seervai· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

C. L. Walker

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

Y. Yu, S. M. Gao, Y. Guan, P. Hu, Q. Zhang, J. Liu, B. Jing, Q. Zhao, D. M. Sabatini, M. Abu-Remaileh, S. Y. Jung, M. C. Wang

This study uses proteomic profiling to reveal lysosomal heterogeneity and its role in longevity by identifying protein dynamics and interactions in lysosomes.

eLife · Jan 19, 2024Peer-reviewedCell Biology

ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

M. Si, R. Yu, H. Lin, F. Li, S. Y. Jung, S. Thomas, F. Danesh, Y. Wang, H. Peng, Z. Hu

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

bioRxiv · Oct 22, 2023 · PreprintCell Biology

Modulation of the extracellular matrix by Streptococcus gallolyticus subsp. gallolyticus and importance in cell proliferation

R. Kumar, J. Taylor, A. Jain, S. Y. Jung, Y. Xu

This study shows Streptococcus gallolyticus subsp. gallolyticus upregulates collagen expression in CRC cells, which mediates its ability to promote cell proliferation and tumor growth.

bioRxiv · Mar 14, 2022Microbiology

3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

I. M. Meraz, M. Majidi, B. Fang, F. Meng, L. Gao, R. Shao, R. Song, F. Li, M. J. Ha, Q. Wang, J. Wang, E. J. Shpall, S. Y. Jung, F. Haderk, P. Gui, , J. A. Roth

This study identifies PDK1 as a driver of osimertinib resistance in NSCLC, showing its inhibition sensitizes resistant cells and correlates with disease progression.

bioRxiv · Dec 10, 2021Cancer Biology

A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules

M. Karki, R. K. Jangid, R. N. H. Seervai, J.-P. Bertocchio, T. Hotta, P. Msaouel, S. Y. Jung, S. L. Grimm, C. Coarfa, B. E. Weissman, R. Ohi, K. J. Verhey, C. H. Hodges, R. Dere, I.-Y. Park, , D. N. Tripathi

This study identifies PBRM1 as the first cytoskeletal reader for SETD2-mediated -tubulin methylation, revealing a new role for PBRM1 in mitotic spindle organization and genomic stability.

Science Advances · Apr 2, 2021Peer-reviewedCell Biology

SETD2 is an actin lysine methyltransferase

R. N. H. Seervai, R. K. Jangid, M. Karki, D. N. Tripathi, S. Y. Jung, S. E. Kearns, K. J. Verhey, M. A. Cianfrocco, B. A. Millis, M. J. Tyska, F. M. Mason, W. K. Rathmell, I. Y. Park, R. Dere, C. L. Walker

This study identifies SETD2 as an actin lysine methyltransferase that regulates actin polymerization and cell migration through methylation of the actin cytoskeleton.

bioRxiv · Apr 13, 2020 · PreprintCell Biology

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

L. Bajaj, A. di Ronza, P. Zheng, A. Eblimit, R. Pal, J. Sharma, D. Roman, J. R. Collette, R. N. Sifers, S. Y. Jung, R. Chen, R. Schekman, M. Sardiello

The paper identifies CLN6 and the EGRESS complex as essential for lysosomal enzyme trafficking from the ER to the Golgi, revealing their role in Batten disease pathogenesis.

bioRxiv · Sep 18, 2019Cell Biology