Author

G. I. McFadden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 2 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:plant (other)· 3 Research Focus:metabolism & bioenergetics· 2 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

C. D. Goodman· 2 shared N. J. Katris· 2 shared A. Chokkathukalam· 1 shared A. E. Barry· 1 shared A. F. Cowman· 1 shared A. M. Dungan· 1 shared A. M. Lamb· 1 shared B. E. Sleebs· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

C. D. Goodman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

M. G. Dans, C. Boulet, G. M. Watson, W. Nguyen, J. M. Dziekan, C. Evelyn, K. Reaksudsan, S. Mehra, Z. Razook, N. D. Geoghegan, M. J. Mlodzianoski, C. D. Goodman, D. B. Ling, T. K. Jonsdottir, J. Tong, , P. R. Gilson

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

A single point mutation in the Plasmodium falciparum ftsh1 metalloprotease confers actinonin resistance.

C. D. Goodman, T. Uddin, N. J. Spillman, G. I. McFadden

This study identifies a single point mutation in PfFtsH1 as the cause of actinonin resistance in P. falciparum, confirming PfFtsH1 as the drug's target.

eLife · Jul 17, 2020Peer-reviewedMicrobiology

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

M. Biddau, S. T. R. Kumar, P. Henrich, L. M. Laine, G. J. Blackburn, A. Chokkathukalam, T. B. Li, K. L. Sim, S. L. Hoffman, M. P. Barrett, G. H. Coombs, G. I. McFadden, D. A. Fidock, S. Muller, L. Sheiner

bioRxiv · May 17, 2020 · PreprintCell Biology

Exaiptasia diaphana from the Great Barrier Reef: a valuable resource for coral symbiosis research

A. M. Dungan, L. M. Hartman, G. Tortorelli, R. Belderok, A. M. Lamb, L. Pisan, G. I. McFadden, L. L. Blackall, M. J. H. van Oppen

This paper introduces new Great Barrier Reef Exaiptasia diaphana strains as model organisms for studying cnidarian-microbiome symbiosis and climate resilience.

bioRxiv · Sep 20, 2019Zoology

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling

N. J. Katris, S. Amiar, L. Berry, S. Dass, M. J. Shears, C. Brunet, B. Touquet, M.-A. Hakimi, G. I. McFadden, Y. Yamaryo-Botte, C. Y. Botte

This study shows that apicomplexan parasites adapt to host nutritional changes by shifting lipid acquisition between de novo synthesis and host scavenging, involving apicoplast lipid metabolism and host organelle remodeling.

bioRxiv · Mar 22, 2019Microbiology

Calcium negatively regulates secretion from dense granules in Toxoplasma gondii.

N. J. Katris, G. I. McFadden, G. G. van Dooren, R. F. Waller

This study shows that calcium negatively regulates dense granule exocytosis in Toxoplasma gondii, dependent on calcium-dependent protein kinases TgCDPK1 and TgCDPK3.

bioRxiv · Aug 7, 2018Cell Biology