K. Xu

This study evaluates neutralization resistance and immune evasion mechanisms of SARS-CoV-2 Omicron subvariants against various sera, identifying key mutations driving resistance.

This study identifies mutations in the Omicron subvariant spike protein that reduce fusogenicity and increase endosomal entry, revealing mechanisms behind their immune evasion and pathogenesis.

The paper introduces a phase separation-based method to visualize protein-protein interactions and kinase activities in plants using the SYMPL vector set.

This study investigates how the BA.2.75 SARS-CoV-2 variant evades neutralizing antibodies through specific mutations and shows enhanced cell-cell fusion.

This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

The paper presents a near-atomic structure of the NuA4 complex and shows it has auto-inhibited conformation that becomes active upon substrate and co-factor binding.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

This study identifies gene novelties in Amphioxus genomes that contribute to adaptive traits like immunity, glycolysis, and calcium regulation, offering insights into early deuterostome evolution.

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study identifies a novel immunosuppressive pathway involving Cbl-b-mediated Notch1 degradation and shows that targeting this axis enhances CD8+ T-cell responses and anti-cancer immunity.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study investigates the immune evasion and transmissibility of the SARS-CoV-2 Omicron variant, showing significant immune evasion but restored neutralization with booster doses and increased transmissibility due to a more stable spike protein structure.

The paper identifies two distinct ER tubule forms, R1 and R2, regulated by Rtn4 and Climp63, with functional implications for ER structure and dynamics.

This study identifies the gut microbiome-indoleamine 2,3-dioxygenase (IDO1) axis as a mediator of gestational insulin resistance in mice.

The paper measures diffusion coefficients of four enzymes under catalytic conditions and finds no enhanced diffusion.

The paper investigates how asymmetric actin assembly rescues stalled clathrin-mediated endocytosis by analyzing endocytic dynamics and protein geometry using advanced imaging and computational methods.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

This paper introduces excitation spectral microscopy to enable high multiplexing of fluorescent targets in live cells with low crosstalk and high temporal resolution.

This study identifies a tubular ERGIC (t-ERGIC) formed by SURF4 that enhances ER-to-Golgi transport of specific cargoes through unique structural and functional properties.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

This study investigates how the genetic basis of adaptation differs when it occurs through the evolution of selfing modifiers versus mating-unrelated alleles, showing key differences in fixation probabilities and dominance effects.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study shows that glycolysis fuels PI3K signaling in CD8+ T cells, linking metabolic reprogramming to T cell immunity and suggesting therapeutic targets for infectious diseases and cancer.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.