PCK1 and DHODH drive colorectal cancer liver metastatic colonization and nucleotide biosynthesis under hypoxia
N. Yamaguchi, E. Weinberg, A. Nguyen, M. V. Liberti, H. Goodarzi, Y. Y. Janjigian, P. B. Paty, L. B. Saltz, T. P. Kingham, J. M. Loo, E. d. Stanchina, S. F. Tavazoie
This study identifies PCK1 and DHODH as drivers of colorectal cancer liver metastasis under hypoxia by promoting nucleotide biosynthesis.
bioRxiv · Nov 7, 2019Cancer Biology