Lan Geng

Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope

This paper develops a micro-endoscope probe to simultaneously track multiple neuromodulators in real time using fluorescent sensors, demonstrating its use in brain slices and awake mice.

Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo

The paper develops red-shifted GRAB acetylcholine sensors for multiplex imaging of ACh and other neuromodulators in vivo with high spatiotemporal resolution.

Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex

This study identifies a circuit in the medial prefrontal cortex where oxytocin modulates interneurons to promote social behavior in female rats, even under physiological stress.

A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.

Compartmental Neuropeptide Release Measured Using a New Oxytocin Sensor

The paper develops a new oxytocin sensor to study compartmental OT release in neurons and finds distinct calcium channel roles and fusion machinery differences in axons and somatodendritic regions.