M. Dean

Genetics of Latin American Diversity (GLAD) Project: insights into population genetics and association studies in recently admixed groups in the Americas

The GLAD Project compiles genome-wide data from 54,077 Latin Americans and develops tools for ancestry matching and statistical software evaluation in admixed populations.

Extrachromosomal Amplification of Human Papillomavirus Episomes as a Mechanism of Cervical Carcinogenesis

The paper identifies extrachromosomal HPV16 episomes as a mechanism of cervical carcinogenesis, showing that they can cause cancer without integration through rearranged and multimer episomes.

High-throughput Single-cell CNV Detection Reveals Clonal Evolution During Hepatocellular Carcinoma Recurrence

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

Mineralisation of the Callorhinchus vertebral column (Holocephali; Chondrichthyes)

This study describes the development and mineralisation of the synarcual in elephant sharks and compares it to other holocephalans and elasmobranchs.

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

This paper examines the genetic structure and adaptation of Andean highlanders and Amazonian dwellers, showing how geography and culture influence genetic differentiation and natural selection.

Human papillomavirus 16 positive cervical cancer in Guatemala: The D2 and D3 sublineages differ in integration rate and age of diagnosis

This study compares HPV16 D2 and D3 sublineages in Guatemalan cervical cancer samples, finding differences in integration rates, age of diagnosis, and somatic mutation frequency.

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

Androgen Receptor Signaling Regulates the Transcriptome of Prostate Cancer Cells by Modulating Global Alternative Splicing

This study shows that androgen receptor signaling in prostate cancer cells regulates alternative splicing of genes, contributing to tumor progression and resistance to anti-androgen therapies.

Gene Panel Sequencing in a Chinese High-risk Breast Cancer Cohort

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

Comprehensive analysis of immune evasion in breast cancer by single-cell RNA-seq

This study uses single-cell RNA-seq to analyze the tumor microenvironment of breast cancer, revealing cell type diversity and immune evasion mechanisms.