Author

M. G. Filbin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 7

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J. G. Marques· 2 shared A. Harmelin· 1 shared A. Hill· 1 shared A. Jassim· 1 shared A. Korshunov· 1 shared A. L. Green· 1 shared A. M. Donson· 1 shared A. M. Toland· 1 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. G. Marques

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Natural language processing charts transcriptome evolution to design combination cancer therapies

A. Jassim, B. V. Nimmervoll, S. Terranova, E. Nathan, K. E. Masih, L. Ruff, M. Duarte, E. Cooper, L. P. Hu, G. Katyal, M. Akhbari, R. J. Gilbertson, C. Terhune, G. Balmus, S. P. Jackson, , R. J. Gilbertson

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Progression

S. Savchuk, K. Gentry, W. Wang, E. Carleton, B. Yalcin, Y. Liu, E. C. Pavarino, J. LaBelle, A. M. Toland, P. J. Woo, F. Qu, M. G. Filbin, M. A. Krasnow, B. L. Sabatini, J. Sage, , H. S. Venkatesh

This study shows neuronal activity drives SCLC growth in both primary lung tumors and brain metastases through electrical and calcium signaling mechanisms.

bioRxiv · Jan 19, 2023 · PreprintCancer Biology

An affinity for brainstem microglia in pediatric high grade gliomas of brainstem origin

L. Peretz Zats, L. Ahmad, N. Casden, M. J. Lee, V. Belzer, O. Adato, S. Bar-Cohen, S.-H. B. Ko, M. G. Filbin, R. Unger, D. A. Lauffenburger, R. Segal, O. Behar

This study identifies IL33 as a factor promoting DIPG proliferation in the brainstem microenvironment, highlighting its role in the spatiotemporal pattern of pediatric high-grade gliomas.

bioRxiv · Jun 15, 2022 · PreprintCancer Biology

VRK1 is required in VRK2-methylated cancers of the nervous system

J. So, N. Mabe, B. Englinger, M. Trissal, D. Jeong, E. A. Panditharatna, J. G. Marques, H. Justin, J. Kwon, S. M. Moyer, B. Shim, D. L. Mayhew, K. Stegmaier, M. G. Filbin, W. C. Hahn

The paper identifies VRK1 as a synthetic lethal target in VRK2-methylated nervous system cancers through CRISPR screens and functional studies.

bioRxiv · Dec 28, 2021 · PreprintCancer Biology

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

S. PAL, J. P. Kaplan, H. Nguyen, S. A. Stopka, M. R. Savani, M. S. Regan, Q.-D. Nguyen, K. L. Jones, L. A. Moreau, J. Peng, M. G. Dipiazza, A. Perciaccante, X. Zhu, B. Hunsel, K. X. Liu, , D. Haas-Kogan

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

bioRxiv · Nov 30, 2021Cancer Biology

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

N. Harpaz, T. Mittelman, O. Beresh, O. Griess, N. Furth, T. M. Salame, R. Oren, L. Fellus-Alyagor, A. Harmelin, S. Alexandrescu, J. G. Marques, M. G. Filbin, G. Ron, E. Shema

The paper uses CyTOF to analyze histone modifications in DIPG tumors, identifying two epigenetically distinct subpopulations with differential proliferation and marker expression.

bioRxiv · Nov 2, 2021Cancer Biology