Author

M. Heikenwalder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Rahbari· 3 shared A. J. Rose· 2 shared D. Heide· 2 shared J. E. Barragan Avila· 2 shared S. Gallage· 2 shared A. Ali· 1 shared A. Billeter· 1 shared A. Chung· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

M. Rahbari

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5 papers

Recent·Most cited

Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma

A. Prawira, H. Xu, W. Q. Leow, M. Otsuka, Z. Chen, M. Rahbari, S. N. Hazirah, M. Wasser, A. Chung, B. K. P. Goh, P. K.-H. Chow, S. Albani, J. Lee, T. Lim, W. Zhai, , V. Chew

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

bioRxiv · May 9, 2024 · PreprintImmunology

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPAR alpha and PCK1 action in hepatocytes

S. Gallage, A. Ali, J. E. Barragan Avila, N. Seymen, P. Ramadori, V. Joerke, L. Zizmare, J. Kosla, X. Li, E. Focaccia, S. Yousuf, T. Sijmonsma, M. Rahbari, K. S. Kommoss, A. Billeter, , M. Heikenwalder

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

bioRxiv · Oct 23, 2023 · PreprintCancer Biology

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

S. Gallage, E. E. Irvine, S. Pedroni, J. E. Barragan Avila, S. Khadayate, J. Pombo, S. Brookes, D. Heide, G. Dharmalingam, A. I. Choudhury, N. Herranz, S. Vernia, M. Heikenwalder, J. Gil, D. J. Withers

This study shows that S6K1 deletion reduces inflammation and immune infiltration in aged livers, suggesting it suppresses the inflammatory SASP, contributing to healthspan benefits.

bioRxiv · Oct 17, 2023Physiology

CXCR2 inhibition enables NASH-HCC immunotherapy

J. Leslie, J. B. G. Mackey, T. Jamieson, E. Ramon-Gil, T. M. Drake, F. Fercoq, W. Clark, K. Gilroy, A. Hedley, C. Nixon, S. Luli, M. Laszczewska, R. Pinyol, R. Esteban-Fabro, C. E. Willoughby, , Carlin

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

bioRxiv · Feb 24, 2022Cancer Biology

Restriction of essential amino acids dictates the systemic response to dietary protein dilution

Y. W. Yap, P. M. Rusu, A. Y. Chan, B. C. Fam, A. Jungmann, S. M. Solon-Biet, C. K. Barlow, D. J. Creek, C. Huang, R. B. Schittenhelm, B. Morgan, D. Schmoll, B. Kiens, M. D. Piper, M. Heikenwalder, , A. J. Rose

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.

bioRxiv · Nov 20, 2019 · PreprintPhysiology