M. Joensuu

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors

This study shows that combining PIKfyve and TMPRSS2 inhibitors intranasally protects mice from SARS-CoV-2 lung infection and reduces cell death.

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum

This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.

MOLECULAR VIDEOGAMING: SUPER-RESOLVED TRAJECTORY-BASED NANOCLUSTERING ANALYSIS USING SPATIO-TEMPORAL INDEXING

The paper introduces a new method to analyze SMLM data by incorporating temporal information, revealing transient nanoclusters of syntaxin1a and Munc18-1 on the plasma membrane.

Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells

The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.