C. G. Williams

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Spatial transcriptomics maps molecular and cellular requirements for CD4+ T cell-dependent immunity to malaria.

This paper uses spatial transcriptomics to map CD4+ T cell and B cell interactions in the spleen during malaria infection, revealing their localization and molecular requirements for immunity.

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites

The paper shows that systemic host inflammation slows malaria parasite maturation and alters their transcriptomic profile in vivo.

Marburg and Ebola virus mRNA 3 untranslated regions contain negative regulators of translation that are modulated by ADAR1 editing

This study identifies ADAR1-mediated editing of filovirus 3UTRs as negative regulators of translation, showing that editing or deletion enhances translation and modulates immune responses.

Pulsed broad-spectrum UV light effectively inactivates SARS-CoV-2 on multiple surfaces

This study shows that pulsed broad-spectrum UV light inactivates SARS-CoV-2 on plastic, glass, stainless steel, and N95 respirators at specific UV doses.

Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

This study identifies non-canonical proline-tyrosine interactions in the Ebola virus VP30 protein that regulate viral replication by interacting with multiple host proteins.

Single-cell transcriptomics of allo-reactive CD4+ T cells over time reveals divergent fates during gut GVHD

This study uses single-cell RNA sequencing to track the differentiation of allo-reactive CD4+ T cells during gut GVHD, revealing divergent fates into quiescent and effector states.

Impact of Mengla virus proteins on human and bat innate immune pathways

This paper compares MLAV viral proteins to EBOV and MARV homologs in their ability to modulate innate immune pathways in human and bat cells, identifying similarities and differences in IFN suppression mechanisms.

Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4+ T cells.

This study uses single-cell RNA-seq and ATAC-seq to show a progressive transition from effector to memory CD4+ T cells during Plasmodium infection, with linear pathways and memory-associated gene expression.