Author

M. Lautens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 5 Organism:C. elegans· 3 Research Focus:protein structure prediction· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. R. Burns· 3 shared A. S. Vaidya· 2 shared B. M. Palmeira· 2 shared D. Kulke· 2 shared E. M. Redman· 2 shared I. Franzoni· 2 shared I. Stagljar· 2 shared I. Zasada· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. R. Burns

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Author profile →

6 papers

Recent·Most cited

Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6

R. J. Harding, I. Franzoni, M. K. Mann, M. Szewczyk, B. Mirabi, D. D. Owens, S. Ackloo, A. Scheremetjew, K. A. Juarez-Ornelas, R. Sanichar, R. J. Baker, C. Dank, P. J. Brown, D. Barsyte-Lovejoy, V. Santhakumar, , C. H. Arrowsmith

The paper identifies and characterizes a chemical probe, SGC-UBD253, that targets the HDAC6 UBD with selectivity, and a less active derivative as a negative control.

bioRxiv · Feb 21, 2023Pharmacology & Toxicology

Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential

S. Harrington, J. Pyche, A. R. Burns, T. Spalholz, R. J. Baker, J. Ching, M. Lautens, D. Kulke, W. Deuther-Conrad, P. Brust, P. J. Roy

A small molecule screen identifies a vesicular acetylcholine transporter inhibitor scaffold that incapacitates parasitic nematodes.

bioRxiv · Jun 14, 2022 · PreprintPharmacology & Toxicology

Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release

S. Harrington, J. J. Knox, A. R. Burns, K.-L. Choo, A. Au, M. Kitner, C. Haeberli, J. Pyche, C. D'Amata, Y.-H. Kim, J. Volpatti, M. Guiliani, J. Snider, V. Wong, B. M. Palmeira, , P. Roy

A C. elegans-based screening pipeline identifies a selective nematicide that also potentiates acetylcholinesterase inhibitors.

bioRxiv · Mar 12, 2022 · PreprintPharmacology & Toxicology

Selective Control of Parasitic Nematodes Using Bioactivated Nematicides

A. R. Burns, R. J. Ross, M. Kitner, J. Volpatti, A. S. Vaidya, E. Puumala, B. M. Palmeira, E. M. Redman, J. Snider, S. Marwah, S. W. Chung, M. H. MacDonald, J. Tiefenbach, C. Hu, Q. Xiao, , P. Roy

This study identifies selectivins, a family of imidazothiazole nematicides that are selectively activated in nematodes, offering effective and selective control of plant-parasitic nematodes.

bioRxiv · Mar 11, 2022 · PreprintPharmacology & Toxicology

Identification of the pathway of Rhodoquinone biosynthesis in C. elegans

S. Del Borrello, M. Lautens, K. Dolan, J. H. Tan, M. Spensley, A. Caudy, A. Fraser

This study identifies the pathway for Rhodoquinone biosynthesis in C. elegans and develops an assay to screen for drugs blocking RQ-dependent metabolism.

bioRxiv · May 4, 2019 · PreprintBiochemistry

Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors

R. Ferreira de Freitas, R. Harding, I. Franzoni, M. Ravichandran, M. K. Mann, H. Ouyang, M. Lautens, V. Santhakumar, C. Arrowsmith, M. Schapira

The paper identifies HDAC6 ZnF-UBD inhibitors and describes their structure-activity relationships, revealing key binding features and potential for further optimization.

bioRxiv · Feb 20, 2018Biophysics