Author

O. Fedorova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. M. Pyle· 3 shared A. DeHart· 1 shared A. Iwasaki· 1 shared A. Richmond· 1 shared B. Israelow· 1 shared B. L. Menasche· 1 shared C. B. F. Vogels· 1 shared C. B. Wilen· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioengineering

A. M. Pyle

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sodium/Potassium ATPase Alpha 1 Subunit Fine-tunes Platelet GPCR Signaling Function and is Essential for Thrombosis

O. Q. Li, H. Yue, A. DeHart, R. Roytenberg, R. Aguilar, O. Olanipekun, F. Bai, J. Liu, O. Fedorova, D. Kennedy, E. Thompson, S. Pierre, W. Li

This study shows that NKA 1 enhances platelet GPCR signaling and thrombosis by binding to LGL-containing receptors, and its inhibition reduces thrombosis and sensitizes clopidogrel.

bioRxiv · May 13, 2024 · PreprintCell Biology

A Nanoparticle RIG-I Agonist for Cancer Immunotherapy

L. Wang-Bishop, M. Wehbe, L. E. Pastora, J. Yang, K. M. Garland, K. W. Becker, C. S. Carson, K. N. Gibson-Corley, D. Ulkoski, V. Krishnamurthy, O. Fedorova, A. Richmond, A. M. Pyle, J. T. Wilson

This paper develops SLR-LNPs, a nanoparticle-based RIG-I agonist, showing enhanced tumor immunogenicity and improved response to immune checkpoint inhibitors in mouse cancer models.

bioRxiv · Apr 25, 2023 · PreprintBioengineering

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

T. Mao, B. Israelow, C. Lucas, C. B. F. Vogels, O. Fedorova, M. I. Breban, B. L. Menasche, H. Dong, M. Linehan, Yale SARS-CoV-2 Genome Surveillance Initiative, C. B. Wilen, M. L. Landry, N. D. Grubaugh, A. M. Pyle, A. Iwasaki

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

bioRxiv · Jun 16, 2021Immunology

Structural insights into the role of Dicer-related helicase 3 in RNAi in Caenorhabditis elegans.

K. Li, J. Zheng, M. Wirawan, T. M. Nguyen, O. Fedorova, P. Griffin, A. M. Pyle, D. Luo

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry