Author

M. Lorenzo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Nogales· 2 shared J. Rudolph· 2 shared K. Chiem· 2 shared L. Martinez-Sobrido· 2 shared R. Blasco· 2 shared A. Ashkenazi· 1 shared A. Ashworth· 1 shared A. C. Pontaroli· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

A. Nogales

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

T. H. Pham, K. B. Pahuja, T. J. Hagenbeek, J. Zbieg, C. L. Noland, V. C. Pham, X. Yao, C. M. Rose, K. C. Browder, H.-J. Lee, M. Yu, M. Liang-Chu, S. E. Martin, E. Verschueren, J. Li, , A. Dey

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

bioRxiv · Oct 3, 2023 · PreprintCancer Biology

Vaccinia virus attenuation by codon deoptimization of the A24R gene for vaccine development

M. Lorenzo, A. Nogales, K. Chiem, R. Blasco, L. Martinez-Sobrido

This study attenuates vaccinia virus by codon deoptimization of the A24R gene, creating a safe and protective vaccine candidate against poxvirus infection.

bioRxiv · Jan 23, 2022 · PreprintMicrobiology

Bi-reporter vaccinia virus for tracking viral infections in vitro and in vivo

K. Chiem, M. Lorenzo, J. Rangel-Moreno, M. d. l. L. Garcia-Hernandez, J.-G. Park, A. Nogales, R. Blasco, L. Martinez-Sobrido

This paper introduces bi-reporter vaccinia viruses expressing both fluorescent and luciferase genes to track viral infections in vitro and in vivo, enabling detailed study of infection dynamics and host-pathogen interactions.

bioRxiv · Aug 24, 2021Microbiology

Increasing Grain Yield in Bread Wheat by Selection for High Spike Fertility Index

A. C. Pontaroli, M. P. Alonso, N. E. Mirabella, J. S. Panelo, M. F. Franco, L. S. Vanzetti, M. Lorenzo

The paper assesses the impact of selecting for high spike fertility index (SF) or high grain yield (GY) per se on grain yield and related traits in wheat populations, finding similar GY increases but trade-offs in other traits.

bioRxiv · Oct 30, 2020Plant Biology

Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma

J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.

bioRxiv · Dec 14, 2018 · PreprintCancer Biology