Author

Mark A. Duquette

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Ashwin Srinivasan KumariD· 2 shared Rakesh K. JainiD· 2 shared Ahmed AliiD· 1 shared Anna M. BarbeauiD· 1 shared Anna Shevzov-Zebrun· 1 shared Brian T. DoiD· 1 shared Dai FukumuraiD· 1 shared Dan Gabriel DudaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Ashwin Srinivasan KumarORCID

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2 papers

Recent·Most cited

Targeting Tumor-derived Sphingosine Kinase 2 Unleashes Antitumor Immunity and Improves Survival of Mice with Group 3 Medulloblastoma

Sampurna Chatterjee, Pragya Kumar, Ashwin Srinivasan Kumar, Pin‐Ji Lei, Meenal Datta, Yuhui Zhao, William W. Ho, Nilesh P. Talele, Patrik Andersson, Mark A. Duquette, Shuji Kitahara, Landry Blanc, Samantha J. Wong, Wilhelmus Josephus Kwanten, David H. Ebb, , Rakesh K. Jain

This study identifies SPHK2 as a therapeutic target in G3MB, showing that its inhibition restores anti-tumor immunity and improves survival in mouse models, with enhanced effects when combined with radiation.

bioRxiv · Aug 14, 2026 · PreprintCancer Biology

Site of breast cancer metastasis is independent of single nutrient levels

Keene L. Abbott, Sonu Subudhi, Raphaël Ferreira, Yetiş Gültekin, Sophie Charlotte Steinbuch, Muhammad Bin Munim, Diya L. Ramesh, Sophie Elisabeth Honeder, Ashwin Srinivasan Kumar, Michelle Wu, Jacob Hansen, Anna Shevzov-Zebrun, Edrees H. Rashan, Kian Moritz Eghbalian, Sharanya Sivanand, , Matthew G. Vander Heiden

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

Nature · Jan 7, 2026Peer-reviewedCancer Biology