Author

Michelle Melanson

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Approach:benchmark study· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Maria Kost‐AlimovaiD· 3 shared Adam P. SkepneriD· 2 shared Amy B. GoodaleiD· 2 shared Anne Elizabeth CarpenteriD· 2 shared Beth A. CiminiiD· 2 shared Briana Fritchman· 2 shared Desiree Hernandez· 2 shared Hamdah Shafqat AbbasiiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Maria Kost‐AlimovaORCID

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Author profile →

4 papers

Recent·Most cited

A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies

Magdalena Riedl Khursigara, Alissa C. Goss, Maria Kost‐Alimova, Keith H. Keller, Christine Danielle De Mata, Ranjithmenon Muraleedharan, Edward Ryan Collantes, Matthew Brown, Elizabeth J. Grinkevich, Felichi Mae Arines, John Lin, Patrick Byrne, Silvana Bazúa‐Valenti, Elizabeth Morici, Julie Roignot, , Anna Greka

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

bioRxiv · Jul 13, 2026 · PreprintCell Biology

The 9p21.3 Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of MTAP

Timothy N. Audam, Benjamin Schmandt, Yi Huang, Young Beum Cho, Mayank Murali, Rama Kaalia, Saaket Agrawal, Jinping Liu, Hongjie Shi, Zhou Yuan, Dengwei Cao, Lan Jiang, Yun Li, Jichen Wen, Zhao Hongqiang, , Melina Claussnitzer

This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.

bioRxiv · Nov 18, 2025 · PreprintGenomics

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

Srinivas Niranj Chandrasekaran, Beth A. Cimini, Amy B. Goodale, Lisa Miller, Maria Kost‐Alimova, Nasim Jamali, John G. Doench, Briana Fritchman, Adam P. Skepner, Michelle Melanson, Alexandr A. Kalinin, John Arévalo, Marzieh Haghighi, Juan C. Caicedo, Daniel Kühn, , Anne Elizabeth Carpenter

The paper introduces a dataset of cell morphology images treated with matched chemical and genetic perturbations and evaluates methods for identifying perturbation similarities.

Nature Methods · Apr 9, 2024Peer-reviewedBioinformatics

Optimizing the Cell Painting assay for image-based profiling

Beth A. Cimini, Srinivas Niranj Chandrasekaran, Maria Kost‐Alimova, Lisa Miller, Amy B. Goodale, Briana Fritchman, Patrick J. Byrne, Sakshi Garg, Nasim Jamali, David J. Logan, John B. Concannon, Charles-Hugues Lardeau, Elizabeth Mouchet, Shantanu Singh, Hamdah Shafqat Abbasi, , Anne Elizabeth Carpenter

The paper updates the Cell Painting assay protocol to improve morphological profiling, finding that simplified steps and reduced stain concentrations maintain robust outputs.

Nature Protocols · Jun 21, 2023Peer-reviewedBioinformatics