Author

N. C. Curtis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Lee· 3 shared S. Shin· 3 shared L. M. Walker· 2 shared M. E. Ackerman· 2 shared P. F. Wright· 2 shared R. I. Connor· 2 shared W. F. Wieland-Alter· 2 shared A. Ashare· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

J. Lee

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Author profile →

3 papers

Recent·Most cited

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2

R. I. Connor, M. I. Sakharkar, C. G. Rappazzo, C. I. Kaku, N. C. Curtis, S. Shin, W. F. Wieland-Alter, J. A. Weiner, M. E. Ackerman, L. M. Walker, J. Lee, P. F. Wright

This study identifies infection-enhancing antibodies targeting the N-terminal domain of SARS-CoV-2 spike protein, which persist in convalescent patients and may be counteracted by viral mutations.

bioRxiv · Sep 19, 2023Immunology

Characterization of SARS-CoV-2 Convalescent Patients' Serological Repertoire Reveals High Prevalence of Iso-RBD Antibodies

N. C. Curtis, S. Shin, A. P. Hederman, R. I. Connor, W. F. Wieland-Alter, S. Ionov, J. Boylston, J. Rose, M. Sakharkar, D. B. Dorman, J. A. Dessaint, L. L. Gwilt, A. R. Crowley, J. Feldman, B. M. Hauser, , J. Lee

This study characterizes the serological repertoire of SARS-CoV-2 convalescent patients, revealing a high prevalence of iso-RBD antibodies that do not recognize prefusion-stabilized S, and shows that vaccination with prefusion-stabilized S reduces their prevalence.

bioRxiv · Sep 8, 2023 · PreprintImmunology

Infant antibody repertoires during the first two years of influenza vaccination

M. Kuraoka, N. C. Curtis, A. Watanabe, H. Tanno, S. Shin, K. Ye, E. Macdonald, O. Lavidor, S. Kong, T. Von Holle, I. W. Windsor, G. C. Ippolito, G. Georgiou, E. B. Walter, G. H. Kelsoe, , J. Lee

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

bioRxiv · Sep 13, 2022Immunology