AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack
Katharina G. Wandera, Stefan Schmelz, Angela Migur, Anuja Kibe, Peer Lukat, Tatjana Achmedov, Neva Caliskan, Wulf Blankenfeldt, Chase L. Beisel
This paper shows AcrVIB1 inhibits CRISPR-Cas13b by promoting unproductive crRNA binding and degradation, revealing a mechanism to suppress immune defense.
Molecular Cell · Feb 17, 2025Peer-reviewedBiochemistry